STARD13 Antibody, Biotin conjugated

1. Study elucidated StarD13 messenger RNA as a Competitive endogenous messenger RNA (ceRNA) in regulating migration and invasion of breast cancer cells. MicroRNA-125b was identified to induce metastasis of MCF-7 cells and bind with both StarD13 3'UTR and TP53INP1 3'UTR. Therefore, a ceRNA interaction between StarD13 and TP53INP1 mediated by competitively binding to miR-125b was indicated. PMID: 29146309
2. Low STARD13 expression is associated with metastasis of breast cancer. PMID: 26985770
3. miR-125b functions as an oncogene in gastric cancer and represents a new potential therapeutic target for gastric cancer. PMID: 27220320
4. The tumor suppressor DLC2 and Kif1B are central components of a signaling network that guides spindle positioning, cell-cell adhesion and mitotic fidelity. PMID: 25518808
5. Dimerization of DLC2 was required for its interaction with GKAP, which, in turn, potentiated GKAP self-association. PMID: 24938595
6. Study describes STARD13 as a tumor suppressor playing a positive role in cancer motility. PMID: 24627003
7. The present study further describes the role of StarD13 as a tumor suppressor as well as a Rho GAP. PMID: 24253896
8. Importance of the regulation of RhoA activity in focal adhesions of astrocytoma cells and StarD13 is a GAP playing a major role in this process. PMID: 24333506
9. In the present review, we discuss the family of RhoGTPases, their regulation and their RhoGAPs, focusing mainly on STARD13. [review] PMID: 23316797
10. RhoGAP protein Stard13 is an essential regulator of pancreas tissue architecture in the mammalian embryo; Stard13 acts by regulating Rho signalling spatially and temporally during pancreas development. PMID: 23175628
11. Authors detected an increase in p-ERK in StarD13 knockdown cells, uncovering a potential link between Rho GTPases and ERK activation. PMID: 22614672
12. role of miR-125b in pro-metastasis by targeting STARD13 PMID: 22693547
13. DLC2 inhibits the activity of Raf-1-ERK1/2-p70S6K via its RhoGAP function, resulting in the suppression of cell growth. PMID: 20629949
14. has GAP activity specific for RhoA and Cdc42; inhibits the Rho mediated assembly of actin stress fibers in cultured cells and is underexpressed in hepatocellular carcinoma tissues PMID: 12531887
15. underexpression is associated with poor prognosis in patients with hepatocellular carcinoma PMID: 18651974

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HGNC: 19164

OMIM: 609866

KEGG: hsa:90627

STRING: 9606.ENSP00000338785

UniGene: Hs.156551