Product Details

Uniprot No.

Target Names

STEAP4

Alternative Names

STEAP4; STAMP2; TNFAIP9; Metalloreductase STEAP4; Six-transmembrane epithelial antigen of prostate 4; SixTransMembrane protein of prostate 2; Tumor necrosis factor, alpha-induced protein 9

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthetic peptide of Human STEAP4

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:25-1:100

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Background

Function

Integral membrane protein that functions as NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate. Can also reduce Cu(2+) to Cu(1+). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses. Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation.

Gene References into Functions

These findings suggest that increased STEAP4 mRNA expression is associated with inflammatory stimuli, whereas lower STEAP4 expression is associated with obesity in human islets. PMID: 28405880
STEAP4 plays role in metal homeostasis is critical to the maintenance of cellular homeostasis , and in preventing the onset of metabolic disease. [review] PMID: 28576871
a down regulation of STEAP4 and up-regulation of HIF-1alpha are observed in morbidly obese patients PMID: 27058639
The expression of TNFAIP9 significantly decreased in the adipose tissue of obese children, and its levels are closely related to blood lipid level, insulin resistance, and obesity. PMID: 27706555
the expression of STEAP4 was significantly downregulated in the adipose tissue of obese children. PMID: 27808366
Some SNPs of the STEAP4 gene altered the risk of developing a metabolic syndrome in the Han Chinese population. PMID: 26510124
These data suggest that STAMP2 is required for prostate cancer progression and thus may serve as a novel therapeutic target. PMID: 25680860
may interact with mitochondria [review] PMID: 24643198
Our results show increased mRNA expression of STEAP4 and NGAL in human visceral adipose tissue in obese patients. PMID: 23179203
Our findings revealed that STAMP2 gene polymorphisms are likely to significantly contribute to the risk of MetS in male Han Chinese population. PMID: 23953178
three polymorphisms (rs8122, rs1981529 and rs34741656) of STAMP2 gene may be not related with type 2 diabetes mellitus in Xinjiang Uygur population PMID: 23134829
STEAP4 was highly induced in human adipose cells differentiated in the presence of 1,25D. PMID: 23553608
STAMP2 antagonizes HBx-mediated hepatocyte dysfunction, thereby protecting hepatocytes from hepatitis B virus gene expression. PMID: 23095254
STEAP4 genetic variations are likely to be associated with obesity-related insulin resistance in Uygur Chinese general population. PMID: 21718614
STEAP4 is expressed on monocytes and neutrophils in peripheral blood of patients with rheumatoid arthritis. PMID: 22244520
STEAP4 might potentially suppress the pathogenesis of TNFalpha-induced arthritis such as rheumatoid arthritis. PMID: 21633911
an association of the common variation rs1981529 (Gly75Asp, 224A/G) in the STEAP4 gene with obesity in Uygur general population PMID: 21933608
Decreased STAMP2 expression (mRNA and protein) might reflect visceral adipose dysfunction in subjects with obesity and type 2 diabetes. PMID: 21849520
The knockdown of STEAP4 inhibits insulin-stimulated glucose transport and GLUT4 translocation via the attenuated phosphorylation of Akt, independent of the effects of EEA1. PMID: 21468601
There was no association of the three polymorphisms (rs8122, rs1981529 and rs34741656) in the STAMP2 gene with essential hypertension in Xinjiang Uygur population. PMID: 21287513
STEAP 4 genetic polymorphisms may be associated with metabolic syndrome risk in Chinese Uygur population. PMID: 21287516
Fourteen novel and six known single nucleotide polymorphisms (SNPs) including 2 nonsynonymous SNPs in the STEAP4 gene were identified. SNPs rs8122 and rs1981529 were significantly associated with the metabolic syndrome phenotype in females. PMID: 21044749
common polymorphisms of STAMP2 are unlikely to significantly contribute to the risk of the metabolic syndrome in the general population PMID: 20382686
Results demonstrate that STEAP4 does not influence human adipocyte differentiation, but it participates in regulating the insulin sensitivity of human adipocytes. PMID: 20127040
Human WAT STAMP2 associates with obesity and insulin resistance independently of adiponectin. PMID: 18381574
Down-regulation of STEAP4 is associated with obesity in humans. PMID: 18430367
TIARP/STAMP2 is highly upregulated in 3T3-L1 cells and hMSC-Ad by IL-1beta and might, therefore, modulate proinflammatory and insulin resistance-inducing effects of IL-1beta. PMID: 19289123
STEAP4 associates with focal adhesion kinase (FAK) and regulate the activity of FAK through Y397 phosphorylation. PMID: 19787193

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Subcellular Location

Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.

Protein Families

STEAP family

Tissue Specificity

Ubiquitous. Highly expressed in adipose tissue. Expressed in placenta, lung, heart and prostate. Detected at lower levels in liver, skeletal muscle, pancreas, testis and small intestine. Highly expressed in joints of patients with rheumatoid arthritis and

Database Links

HGNC: 21923

OMIM: 611098

KEGG: hsa:79689

STRING: 9606.ENSP00000369419

UniGene: Hs.521008

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Code	CSB-PA795802
Size	US$166
	Order now
Image	The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA795802(STEAP4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA795802(STEAP4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
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STEAP4 Antibody

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Target Background