STK17B Antibody

Datasheet

Code	CSB-PA022838LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: HepG2 whole cell lysate, Mouse brain tissue All lanes: STK17B antibody at 3µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 43 kDa Observed band size: 43 kDa IHC image of CSB-PA022838LA01HU diluted at 1:300 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) STK17B Polyclonal antibody

Uniprot No.

O94768

Target Names

STK17B

Alternative Names

DAP kinase related apoptosis inducing protein antibody; DAP kinase related apoptosis inducing protein kinase 2 antibody; DAP kinase-related apoptosis-inducing protein kinase 2 antibody; Death associated protein kinase related 2 antibody; DRAK 2 antibody; DRAK2 antibody; Serine/threonine kinase 17b antibody; Serine/threonine kinase 17b apoptosis inducing antibody; Serine/threonine protein kinase 17B antibody; Serine/threonine-protein kinase 17B antibody; ST17B_HUMAN antibody; STK 17B antibody; Stk17b antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Serine/threonine-protein kinase 17B protein (235-366AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The STK17B Antibody (Product code: CSB-PA022838LA01HU) is Non-conjugated. For STK17B Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA022838LB01HU	STK17B Antibody, HRP conjugated	ELISA
FITC	CSB-PA022838LC01HU	STK17B Antibody, FITC conjugated
Biotin	CSB-PA022838LD01HU	STK17B Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:200-1:500

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Phosphorylates myosin light chains. Acts as a positive regulator of apoptosis.

Gene References into Functions

ChIP assays showed that in U937 cells MYB binds to a conserved element upstream of the DRAK2 transcription start site. PMID: 23398943
DRAK2 protein directly binds to the type I TGF-beta receptor and Knockdown of DRAK2 suppresses the tumorigenic ability of breast cancer cells. PMID: 23122956
DRAK2 and protein kinase D form a novel signaling module that controls calcium homeostasis following T cell activation. PMID: 21148796
DRAK2 kinase activity is regulated in a calcium-dependent manner and that Ser(12) phosphorylation is necessary for optimal suppression of T cell activation by this kinase PMID: 17182616
Strong suppression of T cell receptor signals during thymic selection caused by ectopic DRAK2 expression in a DRAK2 transgenic mouse model of autoimmune encephalomyelitis alters the responsiveness of peripheral T cells. PMID: 19542440
Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer. PMID: 19638987

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Subcellular Location

Nucleus. Cell membrane. Endoplasmic reticulum-Golgi intermediate compartment.

Protein Families

Protein kinase superfamily, CAMK Ser/Thr protein kinase family, DAP kinase subfamily

Tissue Specificity

Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal muscle and kidney.

Database Links

HGNC: 11396

OMIM: 604727

KEGG: hsa:9262

STRING: 9606.ENSP00000263955

UniGene: Hs.88297

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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Target Therapy

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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