STMN3 Antibody

Code CSB-PA022859GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
STMN3
Alternative Names
AI604839 antibody; R75323 antibody; RP23-83A14.1 antibody; SCG10-like protein antibody; Scgn10 like protein antibody; Sclip antibody; Stathmin like 3 antibody; Stathmin-3 antibody; STMN3 antibody; STMN3_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human STMN3
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.
Gene References into Functions
  1. our findings demonstrate that SCLIP plays an important role in glioma pathology, and may represent a novel therapeutic strategy against human glioma. PMID: 25511414
  2. Overexpression of ID1 in two different cell lines induced STMN3 and GSPT1 at the transcriptional level, while depletion of ID1 reduced their expression. PMID: 25028095
  3. We found that reduced expression and possibly posttranslational modification of SCLIP following paclitaxel treatment impaired the microtubule-destabilizing effect of SCLIP PMID: 23543364
  4. Specific serine-proline phosphorylation and glycogen synthase kinase 3beta-directed subcellular targeting of stathmin 3/Sclip in neurons PMID: 22577147
  5. Studies suggest that a STAT3-SCLIP interaction is required to preserve SCLIP stability and contributes to the maintenance of normal epithelial morphology. PMID: 19824884
  6. The substantial expression of SCLIP in most tissues points out a novel function outside the nervous system and raises the possibility that its coexpression with stathmin could provide some degree of functional redundancy. PMID: 12676564

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Subcellular Location
Golgi apparatus. Cell projection, growth cone. Cell projection, axon. Cytoplasm, cytosol.
Protein Families
Stathmin family
Tissue Specificity
Neuron specific.
Database Links

HGNC: 15926

OMIM: 608362

KEGG: hsa:50861

STRING: 9606.ENSP00000359070

UniGene: Hs.639609

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