SUCLA2 Antibody

Datasheet

Code	CSB-PA868398ESR2HU
Size	US$166
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Image	Western blot All lanes: SUCLA2 antibody at 0.85µg/ml Lane 1: Rat heart tissue Lane 2: Hela whole cell lysate Lane 3: A549 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 51, 49 kDa Observed band size: 51 kDa Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA868398ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA868398ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SUCLA2 Polyclonal antibody

Uniprot No.

Q9P2R7

Target Names

SUCLA2

Alternative Names

A BETA antibody; A SCS antibody; ATP specific succinyl CoA synthetase subunit beta antibody; ATP specific succinyl CoA synthetase, beta subunit antibody; ATP-specific succinyl-CoA synthetase subunit beta antibody; Mitochondrial succinyl CoA ligase [ADP forming] subunit beta antibody; MTDPS5 antibody; Renal carcinoma antigen NY-REN-39 antibody; Renal carcinoma antigen NYREN39 antibody; SCS betaA antibody; SCS-betaA antibody; SUCB1_HUMAN antibody; Succinate CoA ligase (ADP forming) antibody; Succinate CoA ligase [ADP forming] subunit beta, mitochondrial, succinyl CoA ligase [ADP forming] subunit beta, mitochondrial antibody; Succinate CoA ligase ADP forming beta subunit antibody; Succinate CoA ligase beta subunit antibody; Succinyl CoA ligase [ADP-forming] subunit beta, mitochondrial antibody; Succinyl CoA synthetase beta A chain antibody; Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial antibody; Succinyl-CoA synthetase beta-A chain antibody; SUCLA2 antibody

Raised in

Rabbit

Species Reactivity

Human, Rat

Immunogen

Recombinant Human Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial protein (1-180AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

Gene References into Functions

SUCLA2 mutation is associated with Down syndrome and mitochondrial depletion syndrome. PMID: 28749033
The patient's cells lack the SUCLG1 protein, with significantly reduced levels of SUCLA2 and SUCLG2 protein PMID: 27484306
Sucla2 is related to the developmental stages of mouse spermatogenesis. Knockdown of Sucla2 decreases the viability of mouse spermatocytes by inducing apoptosis via decreased mitochondrial function of the cells. PMID: 27766610
SUCLA2 mutations should be analyzed in patients with slowly progressive encephalomyopathy, even in the absence of methylmalonic aciduria or mitochondrial DNA depletion. PMID: 24986829
This study demonstrated that SUCLA2 is expressed exclusively in neurons in the human cerebral cortex. PMID: 24085565
Identification of a novel mutation in SUCLA2 in two cousins affected with encephalomyopathy, is reported. PMID: 23759946
A novel homozygous mutation in SUCLA2 gene has been associated with severe mitochondrial encephalomyopathies in two Italian siblings. PMID: 23010432
X-linked sideroblastic anemia due to carboxyl-terminal ALAS2 mutations that cause loss of binding to the beta-subunit of succinyl-CoA synthetase (SUCLA2). PMID: 22740690
Mitochondrial DNA depletion, encephalomyopathic form, with methylmalonic aciduria is associated with mutations in SUCLA2, the gene encoding a beta subunit of succinate-CoA ligase. PMID: 19526370
Deficiency of SUCLA2 is associated with encephalomyopathy and mitochondrial DNA depletion. PMID: 15877282

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Involvement in disease

Mitochondrial DNA depletion syndrome 5 (MTDPS5)

Subcellular Location

Mitochondrion.

Protein Families

Succinate/malate CoA ligase beta subunit family, ATP-specific subunit beta subfamily

Tissue Specificity

Widely expressed. Not expressed in liver and lung.

Database Links

HGNC: 11448

OMIM: 603921

KEGG: hsa:8803

STRING: 9606.ENSP00000367923

UniGene: Hs.743361

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Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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