SYNCRIP Antibody

Datasheet

Code	CSB-PA03334A0Rb
Size	US$166
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Image	Western blot All lanes: SYNCRIP antibody at 2µg/ml Lane 1: EC109 whole cell lysate Lane 2: 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/15000 dilution Predicted band size: 70, 66, 63, 59, 47 kDa Observed band size: 70, 36 kDa Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA03334A0Rb at dilution of 1:100 Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA03334A0Rb at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SYNCRIP Polyclonal antibody

Uniprot No.

O60506

Target Names

SYNCRIP

Alternative Names

cytoplasmic RNA-interacting protein antibody; dJ3J17.2 antibody; Glycine and tyrosine rich RNA binding protein antibody; Glycine- and tyrosine-rich RNA-binding protein antibody; GRY RBP antibody; GRY-RBP antibody; GRYRBP antibody; Heterogeneous nuclear ribonucleoprotein Q antibody; hnRNP Q antibody; HNRPQ antibody; HNRPQ_HUMAN antibody; HNRPQ1 antibody; NS1 associated protein 1 antibody; NS1-associated protein 1 antibody; NSAP1 antibody; pp68 antibody; RP1 3J17.2 antibody; Synaptotagmin binding cytoplasmic RNA interacting protein antibody; Synaptotagmin-binding antibody; Syncrip antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Heterogeneous nuclear ribonucleoprotein Q protein (2-191AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SYNCRIP Antibody (Product code: CSB-PA03334A0Rb) is Non-conjugated. For SYNCRIP Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA03334B0Rb	SYNCRIP Antibody, HRP conjugated	ELISA
FITC	CSB-PA03334C0Rb	SYNCRIP Antibody, FITC conjugated
Biotin	CSB-PA03334D0Rb	SYNCRIP Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function.

Gene References into Functions

A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets. PMID: 29483512
our data indicate that hnRNP Q1 is a novel trans-acting factor that binds to Aurora-A mRNA 5'-UTRs and regulates its translation, which increases cell proliferation and contributes to tumorigenesis in colorectal cancer PMID: 28079881
SYNCRIP is required for survival of leukemia cells. SYNCRIP controls the myeloid leukemia stem cell program. PMID: 28436985
The acidic domain is a unique structural feature of the splicing factor SYNCRIP. PMID: 27081926
hnRNPQ6 is required for APOBEC1-enhanced IL8 production. PMID: 25100733
The hnRNP Q is a novel substrate of SHP2 and the SHP2 activity may be also involved in RNA metabolisms via dephosphorylation of hnRNP Q. PMID: 23946508
The inhibitory effect of hnRNP Q on YB-1 mRNA translation can be explained by its ability to pro-mote YB-1 binding to the regulatory element within the YB-1 mRNA 3' UTR. PMID: 23980891
These data indicate that hnRNP Q can stimulate the protein production of HIV-1 Rev-dependent mRNAs without changing mRNA levels and mRNA export, respectively. PMID: 23679954
Data demonstrate that expression levels of hnRNP A1, Q, K, R, and U influence HIV-1 production by persistently infected PMID: 19808671
The overexpression of NSAP1 specifically enhanced HCV IRES-dependent translation, and knockdown of NSAP1 by use of a small interfering RNA specifically inhibited the translation of HCV mRNA. PMID: 15340051
SYNCRIP is transported within the dendrite as a component of mRNA granules PMID: 15475564
methylation of hnRNPQ is important for its nuclear localization PMID: 16765914
Results suggest hnRNPQ interacts via its acidic domain (AcD) with Apobec1 and that this interaction is regulated by AcD phosphorylation. PMID: 17010310
Data demonstrate that hnRNP Q is a splicing modulator of SMN2, further underscoring the potential of hnRNP Q as a therapeutic target for spinal muscular atrophy. PMID: 18794368
Results demonstrate that galectin-3 stabilizes hnRNP Q via complex formation, and reduction in the hnRNP Q level leads to slow proliferation and less susceptibility to 5-FU. PMID: 19137262
SYNCRIP participates in both RNA replication and translation in HCV life cycle. PMID: 19232660

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Subcellular Location

Cytoplasm. Microsome. Endoplasmic reticulum. Nucleus.; [Isoform 1]: Nucleus, nucleoplasm.; [Isoform 2]: Nucleus, nucleoplasm.; [Isoform 3]: Nucleus, nucleoplasm.

Tissue Specificity

Ubiquitously expressed. Detected in heart, brain, pancreas, placenta, spleen, lung, liver, skeletal muscle, kidney, thymus, prostate, uterus, small intestine, colon, peripheral blood and testis.

Database Links

HGNC: 16918

KEGG: hsa:10492

STRING: 9606.ENSP00000358635

UniGene: Hs.571177

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