TACC2 Antibody

Code CSB-PA023066GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
TACC2
Alternative Names
TACC2 antibody; Transforming acidic coiled-coil-containing protein 2 antibody; Anti-Zuai-1 antibody; AZU-1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human TACC2
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker.
Gene References into Functions
  1. This finding suggests that TACC2 may be a useful tool as a candidate biomarker to predict the recurrence and prognosis of hepatocellular carcinoma. PMID: 29843208
  2. These results suggest that TACC2 plays an important role in the cell proliferation of breast carcinoma and therefore immunohistochemical TACC2 status is a candidate of worse prognostic factor in breast cancer cases. PMID: 27333920
  3. Differential expression of the transcripts TACC2 connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes. PMID: 25884766
  4. Data suggest that TACC2 is highly expressed in prostate cancer cells and contributes to cell cycle progression and cell proliferation in androgen-nonresponsive prostate cancer cells; overexpression of TACC2 leads to recurrence of prostate cancer. PMID: 22456197
  5. Results revealed 3 genes highly predictive of event-free survival (EFS), beyond age and MLL status: FLT3, IRX2, and TACC2. PMID: 22210879
  6. TACC2 may mediate an oncogenic effect on breast cancer cells. PMID: 20335520
  7. Defects in TACC2 expression may affect gene regulation, thus contributing to the pathogenesis of some tumors. PMID: 12620397
  8. GCN5L2 is a TACC2-binding protein. PMID: 14767476
  9. Centrosomal TACC2 is required for mitotic spindle maintenance. PMID: 15304323
  10. Simian virus 40 large T antigen interacting with TACC2 is involved in stabilizing microtubules in mitosis. PMID: 19671663

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Subcellular Location
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein Families
TACC family
Tissue Specificity
Strongly expressed in heart, skeletal muscle, brain, prostate, thyroid and trachea.
Database Links

HGNC: 11523

OMIM: 605302

KEGG: hsa:10579

STRING: 9606.ENSP00000334280

UniGene: Hs.501252

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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