TACC3 Antibody

Code CSB-PA105603
Size US$297
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  • Western blot analysis of extracts from 293 cells and HUVEC cells, using TACC3 antibody.
  • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using TACC3 antibody.
  • Immunofluorescence analysis of A549cells, using TACC3 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TACC3 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
ERIC 1 antibody; ERIC-1 antibody; ERIC1 antibody; MGC117382 antibody; MGC133242 antibody; OTTHUMP00000113796 antibody; TACC3 antibody; TACC3_HUMAN antibody; Transforming acidic coiled coil containing protein 3 antibody; Transforming acidic coiled-coil-containing protein 3 antibody
Raised in
Species Reactivity
Synthesized peptide derived from C-terminal of Human TACC3.
Immunogen Species
Homo sapiens (Human)
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
It differs from different batches. Please contact us to confirm it.
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
IHC 1:50-1:100
IF 1:100-1:500
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. May be involved in the control of cell growth and differentiation. May contribute to cancer.
Gene References into Functions
  1. TACC3 was increased in human RCC cell lines, and knockdown of TACC3 inhibited the ability of cell proliferation, migration, invasion, and tumorigenesis in vivo. PMID: 28109075
  2. this study suggests that TACC3 might be an important molecular marker for diagnosis and prognosis of breast cancer PMID: 27258563
  3. Results show that TACC3 region of FGFR3-TACC3 gene fusion can bind and recruit endogenous TACC3 from the spindle. This reduction in TACC3 levels on the mitotic spindle is the primary cause of mitotic defects in urinary bladder. PMID: 28855393
  4. FGFR3-TACC3 is a recurrent resistance mechanism, which can bypass EGFR blockade by all generations of EGFR TKIs in NSCLC. PMID: 28838400
  5. TACC3 rs798766 is associated with increased risk of bladder cancer, and no ethnic difference was found. PMID: 28655970
  6. High levels of TACC3 in human mammary epithelial cells can cause genomic instability possibly in part through destabilizing BRCA1. PMID: 29355525
  7. TACC3 was highly expressed in CCA tissues and predicted a poor prognosis in CCA patients. TACC3 knockdown induced G2/M cycle arrest and suppressed the invasion, metastasis, and proliferation of CCA cells, both in vitro and in vivo. PMID: 27705912
  8. Data indicate that transforming acidic coiled-coil protein-3 (TACC3) promotes CRC progression and could be an independent prognostic factor and a potential therapeutic target for colorectal cancer (CRC). PMID: 27248823
  9. results suggest that TACC3 is an independent prognostic factor and may be a novel therapeutic target for the treatment of ST PMID: 29135996
  10. The combination treatment of SNIPER(TACC3) and bortezomib exhibited a synergistic anticancer activity in several cancer cell lines. PMID: 28192613
  11. Study provides evidence of the significant oncogenic potential of the FGFR3-TACC3 fusion protein. The presence of the TACC coiled-coil domain leads to increased and altered levels of FGFR3 activation, fusion protein phosphorylation, downstream signaling, cellular transformation, proliferation, and viability. PMID: 26869289
  12. Taken together, these findings uncover a supportive role for TACC3 in PCa metastasis, which is mediated by the activation of the Wnt/beta-catenin signaling pathway, suggesting that TACC3 may serve as a prognostic marker in patients with metastatic PCa. PMID: 28336437
  13. our observations identify TACC3 as an oncogene of tumor malignancy, as well as a prognostic and motoring biomarker for glioma patients. PMID: 28273854
  14. The results showed that the expression of TACC3 was downregulated in preeclamptic placentas. PMID: 27572091
  15. TACC3 overexpression was associated with clinicopathological features of aggressiveness, increased EMT-related protein expression, and poor survival, suggesting a potential role for TACC3 as a prognostic biomarker and therapeutic target in HCC PMID: 26219896
  16. Results showed that high level of TACC3 expression was correlated with advanced clinicopathological classifications, and poor prognosis in non-small cell lung cancer patients indicating that TACC3 is a potential prognostic marker. PMID: 26531241
  17. TACC3 is enriched in hepatocellular carcinoma and down-regulation inhibits the proliferation, clonogenicity, and cancer stem cell-like phenotype of HCC cells PMID: 26219398
  18. The measurement of TACC3 protein expression may be beneficial for predicting clinical outcomes for gastric cancer patients PMID: 26133271
  19. TACC3 depletion in human cell lines causes shorter mitotic spindles. co-immunoprecipitation experiments showed reduced binding between TACC3-F543A and Aurora-A. PMID: 26134678
  20. TACC3 is expressed in esophageal squamous cell carcinoma and correlates with poor prognosis PMID: 25760075
  21. FGFR3-TACC3 rearrangements occur in a subset of patients with lung adenocarcinoma. Such patients should be considered for clinical trials featuring FGFR inhibitors. PMID: 25294908
  22. our data demonstrated the oncogenic role of FGFR3-TACC3 in vitro, indicating that FGFR3-TACC3 may be useful as a diagnostic marker and therapeutic target in cancers. PMID: 25535896
  23. TACC3 depletion induces G1 arrest and cell death by activating p38-p53-p21 signaling and triggering a centrosome-mediated cellular stress response. PMID: 25613365
  24. findings suggest that TACC3 could be recruited as a bridge to cooperatively mediate between the HIF-2alpha PAS-B.ARNT PAS-B complex, thereby participating more directly in HIF-dependent gene transcription than previously anticipated PMID: 25627682
  25. findings provide critical information regarding the mechanisms by which TACC3 contributes to genomic instability PMID: 24769898
  26. TACC3 is involved in the regulation of microtubule nucleation at the centrosome and functions in the stabilization of the gamma-tubulin ring complex assembly PMID: 25246530
  27. TACC3 contributes to spindle formation in proliferating cancer cells. PMID: 24077290
  28. TACC3 phosphorylation by Aurora A kinase is required for central spindle assembly. PMID: 23887685
  29. Aurora-A kinase does not regulate TACC3-chTOG complex formation, indicating that Aurora-A solely functions as a recruitment factor for the TACC3-chTOG complex to centrosomes and proximal mitotic spindles. PMID: 24273164
  30. a novel function for TACC3 in EGF-mediated epithelial-mesenchymal transition in cervical cancer PMID: 23936413
  31. [review] TACC3 protein complexes are crucial for proper mitotic spindle assembly and dynamics to prevent faulty cell division and aneuploidy. PMID: 23787465
  32. Self-assembly and sorting of acentrosomal microtubules by TACC3 facilitate kinetochore capture during the mitotic spindle assembly. PMID: 24003142
  33. Identification of a novel oncogenic FGFR3-TACC3 fusion protein in bladder cancer. PMID: 23175443
  34. discovered FGFR3-TACC3 fusions in 4 of 48 glioblastoma samples, but not in any of 43 low-grade glioma samples tested. The fusion, caused by tandem duplication on 4p16.3, led to the loss of the 3'-UTR of FGFR3, blocking gene regulation of miR-99a. PMID: 23298836
  35. Identify TACC3 as a driver of tumorigenesis as well as an inducer of oncogenic epithelial-mesenchymal transition. PMID: 23348690
  36. study reports that a small subset of glioblastoma multiforme tumors harbors oncogenic chromosomal translocations that fuse in-frame the tyrosine kinase coding domains of fibroblast growth factor receptor genes(FGFR1 or FGFR3) to the transforming acidic coiled-coil coding domains of TACC1 or TACC3; the FGFR-TACC fusion protein displays oncogenic activity PMID: 22837387
  37. we have identified a novel submicroscopic duplication involving dosage sensitive genes TACC3, FGFR3, and LETM1. PMID: 21815251
  38. These findings link TACC3 to novel structural and cell division functions of TSC2. PMID: 20237422
  39. multifaceted genomic evaluation of glioblastoma establishes ERRFI1 as a potential candidate tumor suppressor gene and TACC3 as a potential oncogene, and provides insight on targets for oncogenic pathway-based therapy PMID: 21113414
  40. recruitment to spindle poles by clathrin ensures proper spindle assembly and chromosome alignment in mitotic cells through a RanGTP-dependent pathway PMID: 20923838
  41. Data show that ILK performs its centrosome clustering activity in a centrosome-dependent, manner through the microtubule regulating proteins TACC3 and ch-TOG. PMID: 20838383
  42. TACC3 recruits ch-TOG and clathrin to the mitotic spindle. Together the complex forms inter-microtubule bridges in kinetochore fibres. PMID: 21297582
  43. TACC3 controls paclitaxel sensitivity by modulating a premature senescence program. PMID: 20729911
  44. the association between aurora A phosphorylation and spindle apparatus; regulation from aurora A is mediated by CHC in recruiting phospho-TACC3 and subsequently ch-TOG to mitotic spindles. PMID: 20566684
  45. these findings suggest that Cdh1 controls TACC3 protein stability during mitotic exit. PMID: 19823035
  46. REVIEW: genetics, expression, gene expression regulation, and function studies PMID: 12389629
  47. TACC3 has an essential role in spindle assembly and cellular survival PMID: 17675670
  48. Aurora-A and TACC3 interaction is important to control the mitotic spindle organization required for proper chromosome segregation. PMID: 17914111
  49. overexpression of TACC3 may be associated with the mechanisms of chemoresistance, tumor progression, cell proliferation and metastasis PMID: 19148534

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Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole.
Protein Families
TACC family
Database Links

HGNC: 11524

OMIM: 605303

KEGG: hsa:10460

STRING: 9606.ENSP00000326550

UniGene: Hs.104019

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