TAF3 Antibody

Code CSB-PA564583
Size US$297
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  • Western blot analysis of extracts from K562 cells, using TAF3 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TAF3 Polyclonal antibody
Uniprot No.
Target Names
TAF3
Alternative Names
140 kDa TATA box-binding protein-associated factor antibody; Bip2 protein antibody; RNA polymerase II transcription factor TAFII140 antibody; TAF(II)140 antibody; TAF140 antibody; TAF3 antibody; TAF3 RNA polymerase II TATA box binding protein (TBP)-associated factor antibody; TAF3_HUMAN antibody; TAFII-140 antibody; TAFII140 antibody; TAFII155 protein antibody; TATA box binding protein associated factor 3 antibody; TBP-associated factor 3 antibody; Transcription initiation factor TFIID 140 kDa subunit antibody; Transcription initiation factor TFIID subunit 3 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from internal of Human TAF3.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process.
Gene References into Functions
  1. Data show that transcription cofactor TAF3 is required for transcription of the alpha spectrin SPTA1 gene. PMID: 23935956
  2. Study shows that H3K4me3-TAF3 interactions direct global TFIID recruitment to active genes, some of which are p53 targets. Further analyses show that H3K4me3 enhances p53-dependent transcription by stimulating preinitiation complex formation. PMID: 23452851
  3. Study shows that this TAF3 activity is critical for early lineage segregation during stem cell differentiation. PMID: 21884934
  4. Data identified TAF3 as an evolutionarily conserved negative regulator of p53 transcription activation function. PMID: 18549481
Subcellular Location
Nucleus.
Protein Families
TAF3 family
Database Links

HGNC: 17303

OMIM: 606576

KEGG: hsa:83860

STRING: 9606.ENSP00000340271

UniGene: Hs.527688

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7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA
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