TAP2 Antibody, Biotin conjugated

Datasheet
Code CSB-PA22539D0Rb
Size US$299
Uniprot No. Q03519
Protocols ELISA Protocol
Immunogen Recombinant Human Antigen peptide transporter 2 protein (473-615AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Antigen peptide transporter 2 (APT2) (ATP-binding cassette sub-family B member 3) (Peptide supply factor 2) (Peptide transporter PSF2) (PSF-2) (Peptide transporter TAP2) (Peptide transporter involved in antigen processing 2) (Really interesting new gene 11 protein), TAP2, ABCB3 PSF2 RING11 Y1
Immunogen Species Homo sapiens (Human)
Research Area Tags & Cell Markers
Target Names TAP2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.
Involvement in disease Bare lymphocyte syndrome 1 (BLS1)
Subcellular Location Endoplasmic reticulum membrane, Multi-pass membrane protein
Protein Families ABC transporter superfamily, ABCB family, MHC peptide exporter (TC 3.A.1.209) subfamily
Database Links

HGNC: 44

OMIM: 170261

KEGG: hsa:6891

STRING: 9606.ENSP00000364034

UniGene: Hs.502

Pathway Antigen processing and presentation

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