TAP2 Antibody

1. Our findings support the hypothesis that hsa-miR-1270 suppresses the production of TAP2 by binding to this SNP in the 3'-UTR of this gene PMID: 29205500
2. The present study illustrated that the carriage of LMP7 rs2071543-AA and TAP2 rs1800454-AA had a negative effect on treatment response to pegIFN-alpha/RBV among genotype 1 patient with chronic hepatitis C (CHC) in a Chinese Han population PMID: 29039469
3. We replicated the association between the rs2071473 genotype and TAP2 expression by using GTEx data and demonstrated that TAP2 is expressed by decidual stromal cells at the maternal-fetal interface. PMID: 27745831
4. Two eSNPs were associated with fecundability at a FDR of 5%; both were in the HLA region and were eQTLs for the TAP2 gene (P = 1.3x10-4) and the HLA-F gene (P = 4.0x10-4), respectively. PMID: 27447835
5. These results suggest that TAP2 polymorphisms influence TB susceptibility in a Japanese population. PMID: 27325005
6. Deletions of ABCB3 predict good tumor response to neoadjuvant chemotherapy in breast cancer. PMID: 26799285
7. TAP/TPN complex formation is driven by hydrophobic interactions via leucine zipper-like motifs. PMID: 26519531
8. TAP2, HLA-DOA, HLA-DOB, and tapasin loci are novel candidate regions for susceptibility to HCV infection and viral clearance in the Chinese population PMID: 25874709
9. We showed that TAP2 gene has an association with pulmonary tuberculosis in Koreans. PMID: 25846714
10. Our meta-analyses suggested that TAP2-379Ile allele was significantly associated with a 59% increased risk for rheumatoid arthritis PMID: 24972609
11. Results suggested an association between TAP2-565 polymorphism and chronic lymphoid leukemia (CLL). TAP2-665 GG genotype might be a risk factor for CLL, chronic myeloblastic leukemia, and multiple myeloma. PMID: 24175803
12. Three tapasin binding sites on TAP have been described, two of which are located in the N-terminal domains of TAP1 and TAP2. PMID: 24501197
13. Although lung cancer cells bearing the preprocalcitonin ppCT(16-25) epitope display low levels of TAP, restoration of TAP expression inhibits ppCT antigen presentation. PMID: 23302073
14. the N-terminal region of Snm1B forms a complex containing PSF2 and Mus81, while the C-terminal region is important for PSF2-mediated chromatin association. PMID: 23189151
15. Genetic variation in TAP2 was associated with NHL risk overall, and follicular lymphoma risk in particular, and this was independent of other established loci from 6p21.3. PMID: 22911334
16. the N-terminal extension of the TAP2 subunit represents an autonomous domain, which is correctly targeted to and inserted into the endoplasmic reticulum membrane PMID: 22638925
17. Comparison of unpaired 50 primary breast cancer and 33 brain metastases showed lower expression of beta2-microglobulin, transporter associated with antigen processing (TAP) 1, TAP2 and calnexin in the brain lesions. PMID: 22065046
18. Regression analysis revealed that polymorphisms and haplotypes of TAP2 were associated with FEV1 decline by aspirin provocation (P=0.002-0.04) in most of minor homozygotes compared with major homozygotes and AERD development. PMID: 21796142
19. genetic polymorphism is associated with end stage renal disease in patients of North India PMID: 21440064
20. Single cysteine residue within the antigen translocation complex TAP controls the epitope repertoire by stabilizing a receptive conformation. PMID: 20439763
21. The higher frequency of HLA class I antigen and TAP down-regulation in metastases play a role in the clinical course of the disease. PMID: 20204276
22. TAP-impaired HLA class I expression could influence the course of SCC originating in chronic ulcers and could be related to escape from cytotoxic T-lymphocyte surveillance during disease progression. PMID: 20083708
23. Analysis of TAP2 polymorphisms in Finnish individuals with type I diabetes. PMID: 11916171
24. There was a significant difference in the frequencies at position 665 of TAP 2 gene. TAP genes might have modifying effects on the cystic fibrosis phenotype. PMID: 12026214
25. TAP2*Bky2 or its haplotype with DRB1*08032 may be involved in SS-A/Ro antibody production not only in SS but also SLE, indicating that TAP2*Bky2 may be a susceptible gene not only to the disease of SS but also to the SS-A/Ro autoantibody production. PMID: 12729048
26. Expression of TAP2 is not identical to TAP1 in primary melanoma lesions. PMID: 12777979
27. this allele is preferentially associated with the large conserved haplotype HLA DQA1*0501-DQB1*0201-DRB1*0301 and restricted to populations of African origin PMID: 12786999
28. detected the presence of 17 nucleotide sequence variations in the entire coding region of TAP2 in an indigenous Zimbabwean population (Shona ethnic group) PMID: 12826376
29. TAP2 gene polymorphism is not linked to renal cell carcinoma PMID: 12963978
30. The results of this study provide genetic evidence that TAP2 gene codon 565 polymorphism may play a role in rheumatoid arthritis. PMID: 14749980
31. Evidence is provided that that the extended haplotype of TAP2 is distinct in pauciarticular and polyarticular rheumatoid factor negative juvenile idiopathic arthritis patients. PMID: 15343265
32. TAP1-2 gene polymorphisms may, by way of post-transcriptional changes and altered regulation of gene expression, be involve the immune system in the development of primary open-angle glaucoma PMID: 15887980
33. Transmembrane segment 1 (TM1) of core-TAP2 is critical for its heterodimerization with core-TAP1. PMID: 16061226
34. Results suggest the possible role of TAP2 gene polymorphism in the genetic susceptibility to systemic sclerosis . PMID: 16112028
35. TAP variants lacking TAP2 N-terminal domain build peptide-loading complexes (PLC) that fail to generate stable MHC I-peptide complexes, which correlates with a substantially reduced recruitment of accessory chaperones into the PLC PMID: 16210614
36. The TAP2-2 MspI polymorphism might be associated with calcium stone disease. PMID: 16215317
37. Several TAP gene polymorphisms were examined and a TAP2 SNP (rs241448) associated with AD found in two independent case-control samples, especially in carriers of the APOE4 allele. PMID: 16595160
38. Two Pemphigus vulgaris (PV) TAP2 risk alleles were identified (TAP2*C and TAP2*D) implying that TAP2 genes are involved in susceptibility to development of PV. PMID: 16690408
39. These data reveal that the single-site polymorphism of the TAP2 gene at codon 665 may be an indicator for predicting Graves Disease development. PMID: 16721835
40. The main active site required for peptide translocation by TAP1-TAP2 complexes resides at the TAP2 nucleotide binding site. PMID: 17068338
41. Evidence of TAP2 association with type 1 diabetes that is independent of HLA DR-DQ may be based on allele dependence of splicing into isoforms known to have differential peptide selectivities. PMID: 17192492
42. TAP2-651 site is associated with the risk of HBV infection PMID: 17525827
43. First report on the role of TAP2 polymorphisms involved in the diverse pathogenesis of dengue virus infection. PMID: 18071882
44. Allele 665 is associated with cervical cancer, but this is strongly influenced by linkage disequilibrium with human leukocyte antigen DQB1. PMID: 18650831
45. Downregulation of TAP2 is associated with acute myeloid leukaemic blasts. PMID: 19148137

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HGNC: 44

OMIM: 170261

KEGG: hsa:6891

STRING: 9606.ENSP00000364034

UniGene: Hs.502