TAS1R3 Antibody

1. Regarding "consumption of carbohydrates (% energy) and higher amount of sweet foods, respectively...no associations were found for the TAS1R3 alleles." PMID: 29110749
2. TAS1R3 gene rs307355 polymorphism found independent risk factor for dental caries experience by logistic regression & increased risk of caries. Moderate caries (4-7 caries) found to be associated w/TAS1R3 rs307355 heterozygous genotype PMID: 25924601
3. T1R3 gene expression in the tongue is suppressed by chemotherapy. PMID: 26422579
4. The transcripts of TAS1R3 and UCN2 in peripheral blood cells may be considered potential biomarkers of consumption of sugary and fatty food, respectively, to complement data of food-intake questionnaires. PMID: 26168276
5. Five amino acid residues in cysteine-rich domain of human T1R3 were involved in the response for sweet-tasting protein, thaumatin PMID: 23370115
6. T1R3 is a receptor responsible for the detection of calcium by taste. PMID: 22773945
7. Overexpressed the human N-terminal domain of T1R3 in E. coli and found that the refolded protein behaves as a dimer; showed that hT1R3-NTD is functional and capable of binding sucralose with an affinity in the millimolar range. PMID: 22450161
8. amino acid substitutions (F749S and R757C), located in the transmembrane domain of T1R3, severely impair receptor functions in vitro PMID: 21422378
9. The sweet taste receptors (alpha-gustducin and T1R3) are involved in glucose-stimulated secretion of GLP-1 and PYY. PMID: 21324568
10. Allelic polymorphism within the TAS1R3 promoter is associated with human taste sensitivity to sucrose. PMID: 19559618
11. The mechanism of interaction of the sweet protein monellin with T1R2-T1R3 receptor. PMID: 12706725
12. cysteine-rich region of T1R3 has a role in determining responses to intensely sweet proteins PMID: 15299024
13. An immunohistochemistry study to determine whether and where T1R3 may be localized in the liver and pancreas. PMID: 15585941
14. transmembrane domains of human T1R3 bind with lactisole to inhibit sweet taste PMID: 15668251
15. Although T1R2-T1R3 is known to have multiple potential ligand-binding sites to receive a wide variety of sweeteners, the present study is apparently the first to identify the ATD of hT1R3 as a new sweetener-binding region. PMID: 17499612
16. These results show that T1R2 and T1R3 receptors, in addition to their role in taste perception, may also have a role in intrahepatic cholangiocytes. PMID: 17928076
17. Expressed in the sweet/umami gustatory pathways in taste receptor cells and trigeminal neural pathways in transgenic mice. PMID: 18539481
18. The heteromeric G-protein-coupled receptor T1R2:T1R3 responds to a vast array of chemically diverse natural and artificial sweeteners. PMID: 19083128
19. Variations in perception of umami taste correlated with variations in the human TAS1R3 gene. PMID: 19587085

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HGNC: 15661

OMIM: 605865

KEGG: hsa:83756

STRING: 9606.ENSP00000344411

UniGene: Hs.74375