TBC1D1 Antibody

Code CSB-PA803114LA01HU
Size US$166
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Image
  • IHC image of CSB-PA803114LA01HU diluted at 1:500 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • IHC image of CSB-PA803114LA01HU diluted at 1:500 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TBC1D1 Polyclonal antibody
Uniprot No.
Target Names
TBC1D1
Alternative Names
KIAA1108 antibody; TBC 1 antibody; TBC antibody; TBC1 (tre 2/USP6; BUB2; cdc16) domain family; member 1 antibody; TBC1 antibody; TBC1 domain family member 1 antibody; Tbc1d1 antibody; TBCD1_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human TBC1 domain family member 1 protein (566-718AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The TBC1D1 Antibody (Product code: CSB-PA803114LA01HU) is Non-conjugated. For TBC1D1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA803114LB01HU TBC1D1 Antibody, HRP conjugated ELISA
FITC CSB-PA803114LC01HU TBC1D1 Antibody, FITC conjugated
Biotin CSB-PA803114LD01HU TBC1D1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:500-1:1000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells.
Gene References into Functions
  1. TBC1D1-Ser(231) phosphorylation and/or 14-3-3 binding partially mediates AMPK-governed glucose homeostasis and muscle glucose uptake in a context-dependent manner. PMID: 27826658
  2. data demonstrate heterozygous deactivating TBC1D1 mutations in CAKUT patients with a similar renal and ureteral phenotype, and provide evidence that TBC1D1 mutations may contribute to CAKUT PMID: 26572137
  3. AS160 and TBC1D1 phosphorylations were evident 30 min after exercise. PMID: 24876356
  4. Data show that TBC1D1 is expressed and phosphorylated in response to glucose in these cells. PMID: 24239544
  5. Moderate association of rs9852 indicates an influence of TBC1D1 for antipsychotic-induced weight gain. PMID: 23364847
  6. R125W mutation occurs in a location of the TBC1D1 PTB domain that is predicted to have a function in a putative protein:protein interaction. PMID: 23667688
  7. Data suggest that insulin increases phosphorylation of signaling nexus TBC1D1 independent of prior exercise or lipid/Intralipid administration. PMID: 22851577
  8. TBC1D1 is Ser237 phosphorylated and binding capacity to 14-3-3 protein is increased in skeletal muscle following exercise. PMID: 20837646
  9. [review] The question of a mechanism for increased phosphorylation of Ser237-TBC1D1 after exercise has, so far, not had a straightforward experimental approach for a direct answer in humans undergoing in vivo exercise. PMID: 21078596
  10. A single bout of exercise regulates TBC1D1 and AS160 phosphorylation on multiple sites in human skeletal muscle. PMID: 21505148
  11. Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation. PMID: 21454505
  12. coding variant R125W affects obesity susceptibility, delimits the location of an obesity gene at 4q34-35 and identifies a gene/gene interaction that influences the risk for obesity predisposition PMID: 16893906
  13. form of Tbc1d1 also inhibited GLUT4 translocation and that this effect also required a functional GAP domain PMID: 17274760
  14. These results confirm a putative role of TBC1D1 R125W variant in familial obesity predisposition. PMID: 18325908

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Subcellular Location
Nucleus.
Database Links

HGNC: 11578

OMIM: 609850

KEGG: hsa:23216

STRING: 9606.ENSP00000261439

UniGene: Hs.176503

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