TBC1D20 Antibody, Biotin conjugated

Code CSB-PA846594LD01HU
Size US$299 How to order?
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) TBC1D20 Polyclonal antibody
Uniprot No. Q96BZ9
Target Names TBC1D20
Alternative Names TBC1D20; C20orf140; TBC1 domain family member 20
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human TBC1 domain family member 20 protein (1-237AA)
Immunogen Species Homo sapiens (Human)
Conjugate Biotin
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude.
Gene References into Functions
  1. Warburg Micro syndrome is caused by TBC1D20 deficiency. PMID: 26063829
  2. Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans. PMID: 24239381
  3. The NS5A interaction with TBC1D20 and Rab1 is essential for the viral life cycle. PMID: 22491470
  4. These findings add TBC1D20 to the network of host factors regulating HIV replication cycle. PMID: 22260459
  5. TBC1D20 was found to be the first known GAP for Rab1, which is implicated in the regulation of anterograde traffic between the endoplasmic reticulum and the Golgi complex PMID: 17901050

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Involvement in disease Warburg micro syndrome 4 (WARBM4)
Subcellular Location Membrane; Multi-pass membrane protein.
Database Links

HGNC: 16133

OMIM: 611663

KEGG: hsa:128637

STRING: 9606.ENSP00000346139

UniGene: Hs.590876

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