TBCD Antibody, FITC conjugated

Datasheet
Code CSB-PA883599LC01HU
Size US$299
Uniprot No. Q9BTW9
Immunogen Recombinant Human Tubulin-specific chaperone D protein (2-96AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane (PubMed:10722852, PubMed:10831612, PubMed:11847227, PubMed:20740604, PubMed:27666370, PubMed:28158450). Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis (PubMed:27666370). Involved in neuron morphogenesis (PubMed:27666374).
Form Liquid
Conjugate FITC
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Tubulin-specific chaperone D (Beta-tubulin cofactor D) (tfcD) (SSD-1) (Tubulin-folding cofactor D), TBCD, KIAA0988 SSD1 TFCD
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Research Area Cell Biology
Target Names TBCD
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane
Involvement in disease Encephalopathy, progressive, early-onset, with brain atrophy and thin corpus callosum (PEBAT)
Subcellular Location Cell junction, tight junction, Lateral cell membrane, Cytoplasm, Cell junction, adherens junction, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Protein Families TBCD family
Tissue Specificity Ubiquitously expressed.
Database Links

HGNC: 11581

OMIM: 604649

KEGG: hsa:6904

STRING: 9606.ENSP00000347719

UniGene: Hs.464391

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