TBCD Antibody

Code CSB-PA023229GA01HU
Product Type Purified Rabbit Anti human PolyClonal Antibody
Size US$685
Uniprot No. Q9BTW9
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunogen Human TBCD
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB
Storage Buffer PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity purified
Isotype IgG
Alias tubulin folding cofactor D;TBCD;KIAA0988 ;
Immunogen Species Homo sapiens (Human)
Target Names TBCD
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Details Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.
HGNC 11581
MGI 1919686
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Function Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane
Involvement in disease Encephalopathy, progressive, early-onset, with brain atrophy and thin corpus callosum (PEBAT)
Subcellular Location Cell junction, tight junction, Lateral cell membrane, Cytoplasm, Cell junction, adherens junction, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Protein Families TBCD family
Tissue Specificity Ubiquitously expressed.
Database Links

HGNC: 11581

OMIM: 604649

KEGG: hsa:6904

STRING: 9606.ENSP00000347719

UniGene: Hs.464391

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