TBL2 Antibody

Code CSB-PA023237GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
TBL2
Alternative Names
TBL2 antibody; WBSCR13 antibody; UNQ563/PRO1125Transducin beta-like protein 2 antibody; WS beta-transducin repeats protein antibody; WS-betaTRP antibody; Williams-Beuren syndrome chromosomal region 13 protein antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human TBL2
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Gene References into Functions
  1. TBL2 participates in ATF4 translation through its association with the mRNA. PMID: 26239904
  2. association of TBL2 with the 60S subunit was ER stress independent while the TBL2-PERK interaction occurred upon ER stress PMID: 25976671
  3. TBL2 interacts with PERK via the N-terminus proximal region and also associates with eIF2a via the WD40 domain thus modulating stress-signaling and cell survival during endoplasmic reticulum stress. PMID: 25393282
  4. A TERE1-TBL2 complex likely functions in oxidative/nitrosative stress, lipid metabolism, and SXR signaling pathways in its role as a tumor suppressor. PMID: 23564352
Involvement in disease
TBL2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of TBL2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
Database Links

HGNC: 11586

OMIM: 605842

KEGG: hsa:26608

STRING: 9606.ENSP00000307260

UniGene: Hs.647044

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