TBX18 Antibody

Code CSB-PA051300
Size US$297
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  • Western blot analysis of extracts from Jurkat cells, using TBX18 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TBX18 Polyclonal antibody
Uniprot No.
Target Names
TBX18
Alternative Names
T box 18 antibody; T box protein 18 antibody; T box transcription factor TBX18 antibody; T-box protein 18 antibody; T-box transcription factor TBX18 antibody; TBX18 antibody; TBX18_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from internal of Human TBX18.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as transcriptional repressor involved in developmental processes of a variety of tissues and organs, including the heart and coronary vessels, the ureter and the vertebral column. Required for embryonic development of the sino atrial node (SAN) head area.
Gene References into Functions
  1. Tbx18-positive cells represent a part of PE cells in the initial phase of differentiation and subsequently include SMCs as well as fibroblasts. These results indicate that Tbx18-positive cells serve as a PE progenitor to supply a variety of cells that contribute to the formation of coronary arteries. PMID: 28794400
  2. Gene product expressions of SHH, TBX18 and TSHZ3 are statistically higher in patients with UPJ obstruction, when compared with control group. The explanation may be the reactivation of the processes, which had shown their effects in the embryological period, due to the chronic inflammation and long-term micro-trauma created by the disease PMID: 27381532
  3. Data indicate that human T-box 18 (TBX18) gene induces rat adipose-derived stem cells (ADSCs) to differentiate into pacemaker-like cells in the cardiac microenvironment. PMID: 27632938
  4. Mutations in TBX18 cause dominant urinary tract malformations via transcriptional dysregulation of ureter development. PMID: 26235987
  5. The DNA sequence variants within the TBX18 gene promoter identified in ventricular septal defects (VSD) patients may be involved in the VSD etiology. PMID: 23749171
  6. connexin43 transcriptional suppression by TBX18 undermines cardiomyocyte cell-cell electrical coupling PMID: 21205823
  7. Tbx18 interacts with Gata4 and Nkx2-5 and competes Tbx5-mediated activation of the cardiac Natriuretic peptide precursor type a-promoter. Tbx18 down-regulates Tbx6-activated Delta-like 1 expression in the somitic mesoderm in vivo PMID: 17584735

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Involvement in disease
Congenital anomalies of kidney and urinary tract 2 (CAKUT2)
Subcellular Location
Nucleus.
Database Links

HGNC: 11595

OMIM: 143400

KEGG: hsa:9096

STRING: 9606.ENSP00000358677

UniGene: Hs.251830

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