TCEA1 Antibody

1. RNF20, presumably via H2Bub, selectively represses oncogenic genes by interfering with chromatin recruitment of TFIIS, a factor capable of relieving stalled RNA polymerase II. RNF20 inhibits the interaction between TFIIS and the PAF1 complex. PMID: 21596312
2. a role for TFIIS in transcription recovery and re-establishment of the balance between hypo- and hyper-phosphorylated RNAPII after DNA damage repair PMID: 20729154
3. Results indicate that TFIIS is not limiting for the repair of transcription-blocking DNA lesions and thus the present work does not support a role for TFIIS in TC-NER. PMID: 21070792
4. Results provide a model of the RNA polymerase II-transcription elongation factor TFIIS complex from X-ray diffraction data to 3.8 A resolution. PMID: 12914699
5. transcription factor IIF, hepatitis delta antigen, and stimulatory factor II control human RNA polymerase II (RNAP II) pausing and transcript cleavage PMID: 14506279
6. TFIIS has a role in suppression of transient pausing, which is the most important contribution of TFIIS to elongation from a stall position PMID: 15351637
7. Data shpw that SII is a major component of chromatin transcription and strongly synergizes with p300 (histone acetylation) at a step subsequent to preinitiation complex formation. PMID: 16630816
8. PLAG1 protein is overexpressed in epithelial, myoepithelial, and mesenchymal-like tumor cells in tumors with fusions to CHCHD7 and TCEA1. PMID: 16736500

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HGNC: 11612

OMIM: 601425

KEGG: hsa:6917

STRING: 9606.ENSP00000428426

UniGene: Hs.491745