TCEAL7 Antibody

Datasheet

Code	CSB-PA023278GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

Q9BRU2

Target Names

TCEAL7

Alternative Names

TCEAL7 antibody; Transcription elongation factor A protein-like 7 antibody; TCEA-like protein 7 antibody; Transcription elongation factor S-II protein-like 7 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human TCEAL7

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines.

Gene References into Functions

Our study suggests that TCEAL7 might serve as a candidate tumor suppressor and a potential prognostic biomarker in gastric carcinogenesis. PMID: 23372750
alteration of TCEAL7 expression levels in recombination-based alternative lengthening of telomeres and telomerase-positive cells affects hTERT expression PMID: 20454512
TCEAL7 in the negative regulation of NF-kappaB signaling at the basal level by modulating transcriptional activity of NF-kappaB on its target gene promoters in ovarian cells. PMID: 19966855
TCEAL7 is a cell death regulatory protein that is frequently inactivated in ovarian cancers, and may function as a tumor suppressor. PMID: 15870691
A role for candidate tumor-suppressor gene TCEAL7 in the regulation of c-Myc activity, cyclin D1 levels and cellular transformation is reported. PMID: 18806825
TCEAL7 polymorphisms may play a role in the development of invasive serous ovarian cancers. PMID: 19419758

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Subcellular Location

Nucleus.

Protein Families

TFS-II family, TFA subfamily

Tissue Specificity

Highly expressed in normal and fetal brain tissues, and weakly expressed in uterus and ovary. Down-regulated in epithelial ovarian, cervical, prostate, breast, brain and lung cancer cell lines and in brain and ovarian tumors.

Database Links

HGNC: 28336

OMIM: 300771

KEGG: hsa:56849

STRING: 9606.ENSP00000329794

UniGene: Hs.21861

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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