TCEAL7 Antibody

Code CSB-PA863109LA01HU
Size US$166
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  • Western blot
    All lanes: TCEAL7 antibody at 2µg/ml + A549 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 13 kDa
    Observed band size: 13 kDa

  • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA863109LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA863109LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TCEAL7 Polyclonal antibody
Uniprot No.
Target Names
TCEAL7
Alternative Names
TCEAL7 antibody; Transcription elongation factor A protein-like 7 antibody; TCEA-like protein 7 antibody; Transcription elongation factor S-II protein-like 7 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Transcription elongation factor A protein-like 7 protein (1-100AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The TCEAL7 Antibody (Product code: CSB-PA863109LA01HU) is Non-conjugated. For TCEAL7 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA863109LB01HU TCEAL7 Antibody, HRP conjugated ELISA
FITC CSB-PA863109LC01HU TCEAL7 Antibody, FITC conjugated
Biotin CSB-PA863109LD01HU TCEAL7 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines.
Gene References into Functions
  1. Our study suggests that TCEAL7 might serve as a candidate tumor suppressor and a potential prognostic biomarker in gastric carcinogenesis. PMID: 23372750
  2. alteration of TCEAL7 expression levels in recombination-based alternative lengthening of telomeres and telomerase-positive cells affects hTERT expression PMID: 20454512
  3. TCEAL7 in the negative regulation of NF-kappaB signaling at the basal level by modulating transcriptional activity of NF-kappaB on its target gene promoters in ovarian cells. PMID: 19966855
  4. TCEAL7 is a cell death regulatory protein that is frequently inactivated in ovarian cancers, and may function as a tumor suppressor. PMID: 15870691
  5. A role for candidate tumor-suppressor gene TCEAL7 in the regulation of c-Myc activity, cyclin D1 levels and cellular transformation is reported. PMID: 18806825
  6. TCEAL7 polymorphisms may play a role in the development of invasive serous ovarian cancers. PMID: 19419758

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Subcellular Location
Nucleus.
Protein Families
TFS-II family, TFA subfamily
Tissue Specificity
Highly expressed in normal and fetal brain tissues, and weakly expressed in uterus and ovary. Down-regulated in epithelial ovarian, cervical, prostate, breast, brain and lung cancer cell lines and in brain and ovarian tumors.
Database Links

HGNC: 28336

OMIM: 300771

KEGG: hsa:56849

STRING: 9606.ENSP00000329794

UniGene: Hs.21861

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