TCF20 Antibody, FITC conjugated

Code CSB-PA887024LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TCF20 Polyclonal antibody
Uniprot No.
Target Names
TCF20
Alternative Names
TCF20 antibody; KIAA0292 antibody; SPBP antibody; Transcription factor 20 antibody; TCF-20 antibody; Nuclear factor SPBP antibody; Protein AR1 antibody; Stromelysin-1 PDGF-responsive element-binding protein antibody; SPRE-binding protein antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Transcription factor 20 protein (539-704AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator.
Gene References into Functions
  1. Nonsense and one frameshift variant of TCF20 were identified the patients with intellectual disability and postnatal overgrowth. Such de novo variants of TCF20 may represent a novel differential diagnosis in the overgrowth syndrome spectrum. PMID: 27436265
  2. mutations in TCF20 are associated with Autism spectrum disorders PMID: 25228304
  3. SPBP is a transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62. PMID: 24416372
  4. evolutionary conservation of chromatin binding of SPBP and RAI1 PMID: 24205348
  5. Study has identified SPBP as a transcriptional coactivator of AR. We also show that Pax6 inhibits SPBP-mediated enhancement of AR activity on the AR target gene probasin promoter, a repression that was partly reversed by increased expression of SPBP. PMID: 21935435
  6. SPBP behaves as a repressor of activated ERalpha PMID: 15831449
  7. Interaction between SPBP and TopBP1 was found to be mediated by the ePHD domain of SPBP and the BRCT6 domain of TopBP1. PMID: 17913746

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Subcellular Location
Nucleus.
Tissue Specificity
Expressed in most tissues, except in ovary and prostate. Isoform 1 is exclusively expressed in brain, heart and testis, and this form predominates in liver and kidney. Isoform 2 predominates in lung.
Database Links

HGNC: 11631

OMIM: 603107

KEGG: hsa:6942

STRING: 9606.ENSP00000352463

UniGene: Hs.475018

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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