TERF2IP Antibody

1. These data reveal a MAPK pathway-independent switch in response to cAMP signaling during melanoma progression.Implications: The prosurvival mechanism involving the cAMP-EPAC-RAP1 signaling pathway suggest the potential for new targeted therapies in melanoma. PMID: 28851815
2. Rap1 telomeric and non-telomeric functions and potential implications in diabetic cardiomyopathy have been discussed. (Review) PMID: 28853973
3. the cytoplasmic RAP1-NF-kappaB-BCL2 axis represents a key pathway to cisplatin resistance in non-small cell lung cancer cells. PMID: 28518145
4. Rap1GAP functions as a novel suppressor of epithelial mesenchymal transformation and tumor metastasis in gastric cancer, and loss of Rap1GAP predicts poor prognosis. PMID: 28009991
5. The formation of the Rap1-TRF2 complex restored DNA unwinding. PMID: 28981702
6. Rap1 may induce hepatic ischemia reperfusion injury (IRI) through promoting neutrophils inflammatory response. Rap1 may be the potential therapeutic target of attenuating hepatic IRI. PMID: 27050284
7. The Rap1-RIAM-talin axis of integrin activation and blood cell function PMID: 27207789
8. Rap1 activation was dependent on PKA and required Src family kinases and the Rap1 exchanger C3G. PMID: 27531745
9. RAP1 promotes colorectal cell migration through the regulation of Vimentin and RAP1 may act as a potential target for the diagnosis and therapy of CRC. PMID: 28381157
10. Data show that isoform beta2 of the heregulin (HRGbeta2) localizes at telomeres with the telomere-associated proteins TRF2 and RAP1. PMID: 26318724
11. Data indicate telomere-binding protein RAP1 as an interacting partner of isoform beta2 of the heregulin (HRGbeta2). PMID: 26327598
12. In pro-inflammatory macrophages, Rap1 promotes cytokine production via NFkappaB activation favoring a pro-inflammatory environment which may contribute to the development and progression of atherosclerosis. PMID: 26505215
13. Through a combination of biochemical, biophysical and structural approaches, we unveiled a unique mode of assembly between RAP1 and TRF2 PMID: 26748096
14. the conservation of Rap1 reflects its role in transcriptional regulation rather than a function at telomeres. PMID: 25453752
15. These findings reveal Pkp3 as a coordinator of desmosome and adherens junction assembly and maturation through its functional association with Rap1. PMID: 25208567
16. Data show that full-length repressor activator protein 1 (Rap1) binds to full-length telomeric repeat binding factor 2 (TRF2) with high affinity and equimolar ratio. PMID: 25675958
17. C3G/RAP1 activity is involved in the metastatic spread of epithelial ovarian cancer. PMID: 25617801
18. a detailed analysis of individual focal adhesion parameters identified focal adhesion size, sliding and intensity as primary targets of Rap1. PMID: 25447308
19. Nonsense mutations in the TERF2IP gene in familial melanoma: four families carried TERF2IP variants, which included nonsense mutations in both genes (p.Q320X and p.R364X, respectively). PMID: 25505254
20. results indicate that Rap1 miRNA can effectively enhance sensitivity of HepG2 cell line to 5-FU chemotherapy PMID: 24549317
21. Loss of epithelial integrity in tumorigenesis involves activation of RAP1 via exchange protein directly activated by cAMP (EPAC). PMID: 24316969
22. chemokine unresponsiveness in chronic lymphocytic leukemia lymphocytes results from failure of Arf1/phospholipase D1-mediated translocation of Rap1 to the plasma membrane for GTP loading and may be a specific feature of anergy induced by DNA Ags. PMID: 23804711
23. results reveal an effector pathway for Rap1 in the modulation of Rho signaling and actin dynamics, through which Rap1 modulates endothelial barrier function PMID: 23798437
24. These data provide evidence for the involvement of the Epac/Rap1 signaling pathway in cAMP-mediated decidualization of human endometrial stromal cells. PMID: 23352189
25. these results demonstrate PRL-3 as a novel regulator of NF-kappaB signaling pathway through RAP1. PMID: 23178297
26. Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis. PMID: 23241957
27. as hTRF2 recruits hRap1 to telomeric sequences, hRap1 alters the affinity of hTRF2 and its binding preference on telomeric DNA. Moreover, the TRF2-Rap1 complex has higher ability to re-model telomeric DNA PMID: 23086976
28. Data uncover a new Epac-Rap1-dependent pathway by which endothelial cells can regulate WPB exocytosis in response to agonists that signal through cAMP. PMID: 22511766
29. Lyn controls spatial activation of Rap1 by recruiting the CrkL-C3G protein complex to the leading edge PMID: 21628423
30. Study investigated the binding sites of telomeric proteins along human chromosomes; RAP1 and TRF2 could be found on a small number of interstitial sites, including regions that are proximal to genes. PMID: 21423278
31. Mouse gene deletion experiments revealed DNA-damage-response pathways that threaten chromosome ends and how the components of the telomeric shelterin complex prevent activation of these pathways.[Shelterin] PMID: 21209389
32. N-terminal myr-tagged SKAP1 for membrane binding facilitated constitutive RapL membrane and Rap1 binding and effectively substituted for PI3K and TCR ligation in the activation of LFA-1 in T cells. PMID: 21669874
33. Rap1 controls cadherin function to regulate somal translocation in the neocortex. PMID: 21315259
34. play a role in telomere regulation and may contribute to the telomeric fusions and chromosomal abnormalities observed in ulcerative colitis; a biomarker for associated cancer risk PMID: 20061197
35. Data found that Rap1 binds to both telomeres and to extratelomeric sites through the (TTAGGG)(2) consensus motif. Extratelomeric Rap1-binding sites were enriched at subtelomeric regions. PMID: 20622869
36. levels of Rap1 are positively regulated by NF-kappaB, and human breast cancers with NF-kappaB hyperactivity show elevated levels of cytoplasmic Rap1. PMID: 20622870
37. Data show that actin bundle formation and subsequent linkage between actin bundles and VE-cadherin through alpha- and beta-catenins are important for the stabilization of VE-cadherin at the cell-cell contacts in cAMP-Epac-Rap1 signal-activated cells. PMID: 20032304
38. TRF2/RAP1 prevents classical-non-homologous end-joining-mediated end fusion at the initial DNA-dependent protein kinase end binding and activation step. PMID: 20407424
39. Findings provide the first demonstration that the interplay between Rap1 and E-cadherin along the endocytic recycling pathway serves as a timely and efficient mechanism to regulate hESC self-renewal. PMID: 20039365
40. OZF overexpression in tumours may alter the balance between hRap1 and other telomeric proteins PMID: 15838871
41. Biochemical fractionation and reconstitution revealed that telomere protection is mediated by a RAP1/TRF2 complex, providing evidence for direct role for human RAP1 in protection of telomeric DNA from nonhomologous end-joining at telomeric DNA ends. PMID: 17499040
42. Suggest a role for cAMP/Epac1/Rap1 pathway in regulating proliferation of pancreatic carcinoma cells. PMID: 18580452
43. Rap1-induced activation of both alpha4beta1 and alphaLbeta2 is defective, autocrine VEGF and chemokine are necessary to activate alpha4beta1 for ligand binding. PMID: 18922916

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HGNC: 19246

OMIM: 605061

KEGG: hsa:54386

STRING: 9606.ENSP00000300086

UniGene: Hs.301419