TGIF2 Antibody, Biotin conjugated

Code CSB-PA884421LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TGIF2 Polyclonal antibody
Uniprot No.
Target Names
TGIF2
Alternative Names
5' TG 3' interacting factor 2 antibody; 5''-TG-3''-interacting factor 2 antibody; Homeobox protein TGIF2 antibody; TGF (beta) induced transcription factor 2 antibody; TGF beta induced factor 2 antibody; TGF-beta-induced transcription factor 2 antibody; TGFB induced factor 2 antibody; TGFB-induced factor 2 antibody; Tgif2 antibody; TGIF2_HUMAN antibody; Transforming growth factor beta induced factor 2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Homeobox protein TGIF2 protein (82-222AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.
Gene References into Functions
  1. Tgifs regulate ciliogenesis and suggests that Evi5l mediates at least part of this effect. PMID: 27956704
  2. Authors suggest that miR-148a inhibits OC cell proliferation and invasion partly through inhibition of TGFI2. Therefore, this study highlights the importance of the miR-148a/TGFI2 axis in the malignant progression of OC. PMID: 27712592
  3. Data show that TGFB-induced factor 2 protein (TGIF2) is involved in microRNA miR-541-3p-regulated cell proliferation, invasion, migration, as well as cell cycle of non-small lung cancer (NSCLC) cells. PMID: 27448300
  4. expression of miR-148a was regulated by DNA methylation and targeted by TGIF2. Its methylation may be a potential prognostic indicator in skin cancer PMID: 26638007
  5. miR-34a could inhibit tumor invasion and metastasis in gastric cancer by targeting Tgif2 PMID: 26464633
  6. Corneal fibroblasts demonstrate the expression of TGIF1 and TGIF2 transcription factors. These transcriptional repressors are critical, at least partially, in mediating the antifibrotic effect of vorinostat in the cornea. PMID: 26330748
  7. Shows that the homologous mouse Tgif2 gene is necessary for gastrulation. PMID: 20040491

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Subcellular Location
Nucleus. Note=Excluded from nucleoli.
Protein Families
TALE/TGIF homeobox family
Tissue Specificity
Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate.
Database Links

HGNC: 15764

OMIM: 607294

KEGG: hsa:60436

STRING: 9606.ENSP00000362979

UniGene: Hs.632264

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