THNSL2 Antibody

Code CSB-PA023500GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
THNSL2
Alternative Names
THNSL2 antibody; Threonine synthase-like 2 antibody; TSH2 antibody; EC 4.2.3.- antibody; Secreted osteoclastogenic factor of activated T-cells antibody; SOFAT antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human THNSL2
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate.; Potent inducer of osteoblastic production of IL6. May act to exacerbate inflammation and/or bone turnover under inflammatory conditions.
Gene References into Functions
  1. Our results provide evidence for new loci influencing abdominal visceral (BBS9, ADCY8, KCNK9) and subcutaneous (MLLT10/DNAJC1/EBLN1) fat, and confirmed a locus (THNSL2) previously reported to be associated with abdominal fat in women. PMID: 26480920
  2. These data support a putative role of SOFAT in the bone loss associated with chronic periodontal disease. PMID: 27035849
  3. may exacerbate inflammation and support osteoclast formation and bone destruction PMID: 25916677
  4. The present study demonstrated that SOFAT may play an important role in periodontitis. PMID: 23619471
  5. THNSL2 was found to have bimodal expression in human skeletal muscle tissue. PMID: 21299892
  6. A cytokine named SOFAT (secreted osteoclastogenic factor of activated T cells) can induce osteoblastic IL-6 production and osteoclast formation in the absence of osteoblasts or RANKL. It is insensitive to RANKL inhibitor osteoprotegerin. PMID: 19877052

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Subcellular Location
[Isoform SOFAT]: Secreted. Note=Secreted by activated T-cells via a calcineurin-independent pathway.
Protein Families
Threonine synthase family
Database Links

HGNC: 25602

OMIM: 611261

KEGG: hsa:55258

STRING: 9606.ENSP00000327323

UniGene: Hs.739080

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