THNSL2 Antibody

Datasheet

Code	CSB-PA803155LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate All lanes: THNSL2 antibody at 4.3μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 55, 46, 43, 48, 28 kDa Observed band size: 55 kDa IHC image of CSB-PA803155LA01HU diluted at 1:400 and staining in paraffin-embedded human ovarian cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) THNSL2 Polyclonal antibody

Uniprot No.

Q86YJ6

Target Names

THNSL2

Alternative Names

THNSL2 antibody; Threonine synthase-like 2 antibody; TSH2 antibody; EC 4.2.3.- antibody; Secreted osteoclastogenic factor of activated T-cells antibody; SOFAT antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Threonine synthase-like 2 protein (295-441AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The THNSL2 Antibody (Product code: CSB-PA803155LA01HU) is Non-conjugated. For THNSL2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA803155LB01HU	THNSL2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA803155LC01HU	THNSL2 Antibody, FITC conjugated
Biotin	CSB-PA803155LD01HU	THNSL2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:200-1:500

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate.; Potent inducer of osteoblastic production of IL6. May act to exacerbate inflammation and/or bone turnover under inflammatory conditions.

Gene References into Functions

Our results provide evidence for new loci influencing abdominal visceral (BBS9, ADCY8, KCNK9) and subcutaneous (MLLT10/DNAJC1/EBLN1) fat, and confirmed a locus (THNSL2) previously reported to be associated with abdominal fat in women. PMID: 26480920
These data support a putative role of SOFAT in the bone loss associated with chronic periodontal disease. PMID: 27035849
may exacerbate inflammation and support osteoclast formation and bone destruction PMID: 25916677
The present study demonstrated that SOFAT may play an important role in periodontitis. PMID: 23619471
THNSL2 was found to have bimodal expression in human skeletal muscle tissue. PMID: 21299892
A cytokine named SOFAT (secreted osteoclastogenic factor of activated T cells) can induce osteoblastic IL-6 production and osteoclast formation in the absence of osteoblasts or RANKL. It is insensitive to RANKL inhibitor osteoprotegerin. PMID: 19877052

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Subcellular Location

[Isoform SOFAT]: Secreted. Note=Secreted by activated T-cells via a calcineurin-independent pathway.

Protein Families

Threonine synthase family

Database Links

HGNC: 25602

OMIM: 611261

KEGG: hsa:55258

STRING: 9606.ENSP00000327323

UniGene: Hs.739080

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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