THNSL2 Antibody

Code CSB-PA803155LA01HU
Size US$166
Order now
Image
  • Western Blot
    Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate
    All lanes: THNSL2 antibody at 4.3μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 55, 46, 43, 48, 28 kDa
    Observed band size: 55 kDa

  • IHC image of CSB-PA803155LA01HU diluted at 1:400 and staining in paraffin-embedded human ovarian cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

The Latest Promotion Free Antibody trial simple
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) THNSL2 Polyclonal antibody
Uniprot No.
Target Names
THNSL2
Alternative Names
THNSL2 antibody; Threonine synthase-like 2 antibody; TSH2 antibody; EC 4.2.3.- antibody; Secreted osteoclastogenic factor of activated T-cells antibody; SOFAT antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Threonine synthase-like 2 protein (295-441AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The THNSL2 Antibody (Product code: CSB-PA803155LA01HU) is Non-conjugated. For THNSL2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA803155LB01HU THNSL2 Antibody, HRP conjugated ELISA
FITC CSB-PA803155LC01HU THNSL2 Antibody, FITC conjugated
Biotin CSB-PA803155LD01HU THNSL2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:200-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate.; Potent inducer of osteoblastic production of IL6. May act to exacerbate inflammation and/or bone turnover under inflammatory conditions.
Gene References into Functions
  1. Our results provide evidence for new loci influencing abdominal visceral (BBS9, ADCY8, KCNK9) and subcutaneous (MLLT10/DNAJC1/EBLN1) fat, and confirmed a locus (THNSL2) previously reported to be associated with abdominal fat in women. PMID: 26480920
  2. These data support a putative role of SOFAT in the bone loss associated with chronic periodontal disease. PMID: 27035849
  3. may exacerbate inflammation and support osteoclast formation and bone destruction PMID: 25916677
  4. The present study demonstrated that SOFAT may play an important role in periodontitis. PMID: 23619471
  5. THNSL2 was found to have bimodal expression in human skeletal muscle tissue. PMID: 21299892
  6. A cytokine named SOFAT (secreted osteoclastogenic factor of activated T cells) can induce osteoblastic IL-6 production and osteoclast formation in the absence of osteoblasts or RANKL. It is insensitive to RANKL inhibitor osteoprotegerin. PMID: 19877052

Show More

Hide All

Subcellular Location
[Isoform SOFAT]: Secreted. Note=Secreted by activated T-cells via a calcineurin-independent pathway.
Protein Families
Threonine synthase family
Database Links

HGNC: 25602

OMIM: 611261

KEGG: hsa:55258

STRING: 9606.ENSP00000327323

UniGene: Hs.739080

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*