THOC6 Antibody

Datasheet

Code	CSB-PA769793LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: K562 whole cell lysate, SH-SY5Y whole cell lysate All lanes: THOC6 antibody at 1:2000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 38, 35, 33 kDa Observed band size: 35 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) THOC6 Polyclonal antibody

Uniprot No.

Q86W42

Target Names

THOC6

Alternative Names

THOC6 antibody; WDR58 antibody; PSEC0006 antibody; THO complex subunit 6 homolog antibody; Functional spliceosome-associated protein 35 antibody; fSAP35 antibody; WD repeat-containing protein 58 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human THO complex subunit 6 homolog protein (56-315AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The THOC6 Antibody (Product code: CSB-PA769793LA01HU) is Non-conjugated. For THOC6 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA769793LB01HU	THOC6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA769793LC01HU	THOC6 Antibody, FITC conjugated
Biotin	CSB-PA769793LD01HU	THOC6 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development.

Gene References into Functions

Results indicate three unrelated patients with bi-allelic mutations in THOC6 associated with intellectual disability and additional clinical features. PMID: 27102954
In addition to confirming the morbid nature of THOC6 by providing an independent homozygous apparently loss of function allele in a patient with a compatible phenotype, our data also expand THOC6-related phenotype to include previously unreported imperforate anus and undescended testicles. PMID: 26739162

Involvement in disease

Beaulieu-Boycott-Innes syndrome (BBIS)

Subcellular Location

Nucleus. Nucleus speckle.

Protein Families

WD repeat THOC6 family

Database Links

HGNC: 28369

OMIM: 613680

KEGG: hsa:79228

STRING: 9606.ENSP00000326531

UniGene: Hs.412304

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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