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TIMM23 Antibody

Datasheet
Code CSB-PA023553ESR2HU
Size US$166
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Image
  • Western Blotting(WB) - TIMM23 Antibody

    Western blot
    All lanes: TIMM23 antibody at 3.03µg/ml
    Lane 1: Rat heart tissue
    Lane 2: Mouse liver tissue
    Lane 3: A431 whole cell lysate
    Lane 4: MCF-7 whole cell lysate
    Lane 5: Jurkat whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 22 kDa
    Observed band size: 22 kDa

  • Immunohistochemistry(IHC) 1- TIMM23 Antibody

    Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA023553ESR2HU at dilution of 1:100

  • Immunohistochemistry(IHC) 2- TIMM23 Antibody

    Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA023553ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TIMM23 Polyclonal antibody
Uniprot No.
O14925
Target Names
TIMM23
Alternative Names
TIMM23 antibody; TIM23 antibody; Mitochondrial import inner membrane translocase subunit Tim23 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant Human Mitochondrial import inner membrane translocase subunit Tim23 protein (1-209AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

The rabbit was immunized with recombinant human TIMM23 protein (1-209aa) to produce the TIMM23 polyclonal antibody, which is an IgG isoform and exhibits a liquid form. Antigen affinity purification was used to purify this antibody. This TIMM23 antibody shows reactivity with the TIMM23 protein from human, mouse, and rat species.

This TIMM23 polyclonal antibody has been validated to recognize the TIMM23 protein in ELISA, WB, and IHC assays. TIMM23 is an essential protein found in the mitochondrial inner membrane, which is involved in the translocation of preproteins into mitochondria. Therefore, this TIMM23 polyclonal antibody may be utilized to investigate the function and localization of the TIMM23 protein and its role in mitochondrial protein import.

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TIMM23 Proteins

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Target Background

Function
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Gene References into Functions
  1. Data indicate the essential role of the GABP transcription factor in activating translocase of inner mitochondrial membrane 23 TIMM23 and TIMM23B expression. PMID: 29413900
  2. The interaction of presequence peptides with Tim23 intermembrane space domain is weakened in presence of Ca2+ ion, which implicates that Ca2+ ion may play an important role in the protein import by TIM23 complex. PMID: 27178215
  3. Modulating the sorting of nuclear-encoded proteins into mitochondria, mediated by the TIM23 complex, proves therapeutic in both yeast and patient-derived cells exhibiting ATP synthase deficiency. PMID: 25519239
  4. Three distinct Tim23 complexes, namely, B1, B2, and A, are involved in the maintenance of normal mitochondrial function. PMID: 24636990
  5. GST pull-down experiments and tryptophan fluorescence indicated that there is no interaction between Tim23IMS and Tim50IMS PMID: 23811401
  6. MCJ functions as J co-chaperone of the human TIM23 pre-protein translocase. PMID: 23263864
  7. Study establishes an unexpected molecular link between the TIM23 transport machinery and assembly of respiratory-chain complexes that regulate mitochondrial protein synthesis in response to their assembly state. PMID: 23260140
  8. The non-bound hydrophilic domain of the human Tim23 is in a molten globule configuration with marginal stability, existing as a dimer. PMID: 22306744

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Subcellular Location
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein Families
Tim17/Tim22/Tim23 family
Database Links

HGNC: 17312

OMIM: 605034

KEGG: hsa:100287932

STRING: 9606.ENSP00000260867

UniGene: Hs.524308

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