TMPRSS15 Antibody

Datasheet

Code	CSB-PA018824ESR2HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA018824ESR2HU at dilution of 1:100 Immunoprecipitating PRSS7 in Jurkat whole cell lysate Lane 1: Rabbit control IgG instead of CSB-PA018824ESR2HU in Jurkat whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000) Lane 2: CSB-PA018824ESR2HU (8μg) + Jurkat whole cell lysate (500μg) Lane 3: Jurkat whole cell lysate (10μg)
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TMPRSS15 Polyclonal antibody

Uniprot No.

P98073

Target Names

TMPRSS15

Alternative Names

TMPRSS15; ENTK; PRSS7; Enteropeptidase; Enterokinase; Serine protease 7; Transmembrane protease serine 15

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Enteropeptidase protein (40-300AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC, IP

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IP	1:200-1:2000

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunoprecipitation (IP) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.

Gene References into Functions

The Y174R variant showed improved specificities for substrates containing the sequences DDDDK (kcat/KM = 6.83 x 106 M-1 sec-1) and DDDDR (kcat/KM = 1.89 x 107 M-1 sec-1) relative to all other enteropeptidase variants reported to date. PMID: 23436726
Enteropeptidase is a gene associated with a starvation human phenotype and a novel target for obesity treatment PMID: 23185382
Human enteropeptidase shows 10x faster kinetics compared to other animal sources but low solubility under low salt conditions. A supercharged variant of enteropeptidase light chain with increased solubility was used for crystallization. PMID: 22488687
Characterization of the different catalytic activity of human and bovine enteropeptidase light chains toward hydrolysis of peptides and proteins lacking tetraaspartate sequence. PMID: 22571433
Engineered recombinant enteropeptidase catalytic subunit: effect of N-terminal modification PMID: 11913964
Produced in enterocytes and goblet cells. Localization on brush border of cells for physiological activation of digestive enzymes. In duodenal polyps and adenocarcinoma at duodenum but not in Brunner's gland adenoma. PMID: 12907431
Enterokinase directly cleaved proMMP-9 at the Lys65-Ser66 site. PMID: 18062964

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Involvement in disease

Enterokinase deficiency (ENTKD)

Subcellular Location

Membrane; Single-pass type II membrane protein.

Protein Families

Peptidase S1 family

Tissue Specificity

Intestinal brush border.

Database Links

HGNC: 9490

OMIM: 226200

KEGG: hsa:5651

STRING: 9606.ENSP00000284885

UniGene: Hs.149473

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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