TNFAIP1 Antibody

Datasheet

Code	CSB-PA622686LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA622686LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA622686LA01HU at dilution of 1:100 Immunofluorescent analysis of Hela cells using CSB-PA622686LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TNFAIP1 Polyclonal antibody

Uniprot No.

Q13829

Target Names

TNFAIP1

Alternative Names

TNFAIP1 antibody; BACURD2 antibody; EDP1BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 antibody; hBACURD2 antibody; BTB/POZ domain-containing protein TNFAIP1 antibody; Protein B12 antibody; Tumor necrosis factor antibody; alpha-induced protein 1 antibody; endothelial antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 protein (233-316AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The TNFAIP1 Antibody (Product code: CSB-PA622686LA01HU) is Non-conjugated. For TNFAIP1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA622686LB01HU	TNFAIP1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA622686LC01HU	TNFAIP1 Antibody, FITC conjugated
Biotin	CSB-PA622686LD01HU	TNFAIP1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.

Gene References into Functions

TNFAIP1 silence significantly increased the migrated and invaded cells compared to that in control, while these increases were abolished by miR-424 suppression. PMID: 28535539
CREB is a negative regulator of the TNFAIP1 gene. PMID: 26398148
TNFAIP1 plays an important role in mediating miR-15a dependent biological functions in osteosarcoma. PMID: 26261520
MiR-181a played a critical role in regulating pancreatic cancer growth and migration, likely interacting with TNFAIP1. PMID: 26152285
Results showed that the expression of TNFAIP1 protein was significantly increased in osteosarcoma tissues and associated with distant metastasis. PMID: 24969828
Expression of TNFAIP1 is regulated by the transcriptional factor Sp1. PMID: 23912453
TNFAIP1 inhibited the transcriptional activities of nuclear factor kappa B (NF-kappaB) and activating protein-1 reporters PMID: 22810651
CK2 could phosphorylate TNFAIP1 in vitro and in vivo, which facilitated the distribution of TNFAIP1 in nucleus and enhanced its interaction with PCNA. PMID: 19851886
The promoter region of human TNFAIP1 gene was functionally characterized. PMID: 19593659
suggest that the TNFAIP1/POLDIP2 complex sense-antisense architecture represents a clinically significant transcriptional structural-functional gene module associated with amplification of the genomic region on 17q11.2 in breast cancer. PMID: 20158880
TNFAIP1 shows increased transcript levels in Alzheimer's disease brains PMID: 12600716
Expression levels of TNFAIP1 are high in COS7 and NIH3T3 cell lines but low in the cancer cell lines. PMID: 16870576

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Subcellular Location

Cytoplasm. Nucleus. Endosome. Note=Colocalizes with RHOB in endosomes.

Protein Families

BACURD family

Database Links

HGNC: 11894

OMIM: 191161

KEGG: hsa:7126

STRING: 9606.ENSP00000226225

UniGene: Hs.76090

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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