TNN Antibody, Biotin conjugated

Code CSB-PA892498LD01HU
Size US$299
Uniprot No. Q9UQP3
Protocols ELISA Protocol
Immunogen Recombinant Human Tenascin-N protein (441-556AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity) (PubMed:17909022). Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity). During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (By similarity). In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:17909022).
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Tenascin-N (TN-N) (Tenascin-W) (TN-W), TNN, TNW
Immunogen Species Homo sapiens (Human)
Research Area Others
Target Names TNN
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Extracellular matrix protein that seems to be a ligand for ITGA8
Subcellular Location Secreted, extracellular space, extracellular matrix
Protein Families Tenascin family
Tissue Specificity Not detected in normal adult mammary tissues or brain but expressed in most breast tumors and brain tumors, such as glioblastomas, astrocytomas and oligodendrogliomas, tested (PubMed:17909022, PubMed:19884327). In brain tumors, detected around the endothe
Database Links

HGNC: 22942

OMIM: 617472

KEGG: hsa:63923

STRING: 9606.ENSP00000239462

UniGene: Hs.156369

Pathway PI3K-Akt signaling pathway
Focal adhesion

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