TOB1 Antibody

1. MiR-590 targets Tob1 that is significantly decreased in patients with multiple sclerosis. PMID: 28947212
2. The dual-luciferase reporter assay also confirmed that miR-25 harbored the A allele which caused an incapacitation of binding at the TOB1. In conclusion, rs41274221 in miR-25 was a subgroup which may protect the patients from further growth and metastasis of gastric cancer and might serve as a novel biomarker for the disease PMID: 26572149
3. A novel role for TOB1 in mediating survival of estrogen-independent breast cancers. PMID: 26165839
4. Reduced TOB1 expression in gastric adenocarcinoma is associated with the extent of differentiation and the TNM stage of gastric cancer. PMID: 25760308
5. miR-25 promotes GC progression by directly downregulating TOB1 expression, and may be a noninvasive biomarker for the prognosis of GC patients. PMID: 25043310
6. arsenite-induced oxidative stress inhibits deadenylation of mRNA primarily through downregulation of Tob and Pan3, both of which mediate the recruitment of deadenylases to mRNA PMID: 25446091
7. Tob is a key factor in the regulation of c-myc gene expression, which is essential for cell growth. PMID: 23178487
8. TOB1 demonstrated a radioprotective function in the immortalized normal human bronchial epithelial cell line. PMID: 23756562
9. TOB1 modulates the radiosensitivity of lung cancer cells via the MAPK/ERK signaling pathway. PMID: 23589165
10. Cdc7 phosphorylates and interacts with Tob to inhibit the Cul4-DDB1(Cdt2)-dependent Tob degradation. PMID: 23066029
11. study demonstrates that the overexpression of Tob1 inhibits gastric cancer progression by activating Smad4- and inhibiting betacatenin-mediated signaling pathways PMID: 22710759
12. TOB1 overexpression not only increased the expression of the phosphatase and tensin homolog (PTEN), an important tumor suppressor, but also regulated the downstream effectors in the PI3K/PTEN signaling pathway, including Akt, ERK1/2, etc. PMID: 22158108
13. The antiproliferative and the mRNA deadenylation/decay-promoting effects of TOB1 and TOB2 proteins are linked. PMID: 22252318
14. Silencing of HIC1 and TOB1 expression is a common occurrence in gastric cancer and may contribute to the development and progression of the disease. PMID: 21533545
15. Longer survival was associated with hypomethylation at specific CpG sites (e.g. GREB1, TGIF and TOB1) and hypermethylation in other genes (e.g. TMCO5, PTPRN and GUCY2C). PMID: 21577013
16. Together, these results indicate that Tob mediates the recruitment of Caf1 to the target of CPEB3 and elicits deadenylation and decay of the mRNA. PMID: 21336257
17. Tob interactions with Caf1 and a C-terminal domain of PABPC1 PMID: 20595394
18. functions as lateral signal transmitter PMID: 11904957
19. Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system. the C-terminal regions are necessary and sufficient to control the stabilities of BTG1, BTG2, Tob, and Tob2 proteins. PMID: 12135500
20. identified as a MAPK substrate PMID: 12151396
21. Decreased expression or phosphorylation status of tob protein is associated with lung cancer PMID: 14643028
22. N-terminal region of TOB is a functional nuclear export signal. PMID: 15051490
23. Tob is involved in the translational suppression of IL-2 mRNA in anergic T cells through its interaction with iPABP. PMID: 15676026
24. Tob1 is a novel target for degradation by the SCF-Skp2 ubiquitin ligase in a cell line. PMID: 16951159
25. Reverse-transcription polymerase chain reaction confirmed increased expression of GADD45A, BTG2, PDE4B, and CEBPD and downregulation of TOB1 in skeletal muscle intradialysis. PMID: 16997058
26. Subtractive hybridization identified Twisted gastrulation (Tsg) as one of the genes suppressed by Tob. PMID: 17164348
27. Data show that TOB enhances mRNA deadenylation in vivo, and that interaction with PABPC1 is necessary for TOB's deadenylation-enhancing effect. PMID: 17785442
28. antiproliferative region of human Tob (residues 1-138) and intact hCaf1 were co-expressed in Escherichia coli, purified and successfully cocrystallized PMID: 18084094
29. Tob associates with the CCR4-NOT complex. PMID: 18377426
30. positive correlation of TOB1 phosphorylation status with proliferation marker Ki67 suggests that elevated TOB1 phosphorylation might abrogate the antiproliferative effect of TOB1 in breast cancer PMID: 19491269
31. Down-regulation of TOB is associated with breast cancer tumorigenesis. PMID: 19569230

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HGNC: 11979

OMIM: 605523

KEGG: hsa:10140

STRING: 9606.ENSP00000268957

UniGene: Hs.703321