TOP3B Antibody

1. Structural basis of the interaction between TOP3B and the TDRD3 auxiliary factor has been reported. PMID: 28176834
2. Results identified TOP3B gene deletion as candidate gene in the etiology of neurodevelopmental disorders including juvenile myoclonic epilepsy. PMID: 29490292
3. Top3beta mutants lacking either its RNA-binding domain or catalytic residue fail to promote synapse formation, suggesting that Top3beta requires both its mRNA-binding and catalytic activity to facilitate neurodevelopment. PMID: 28039324
4. Top3b proteins from several animals associate with polyribosomes, which are units of mRNA translation, whereas the Top3 homologs from E. coli and yeast lack the association. The Top3b-polyribosome association requires TDRD3, which directly interacts with Top3beta and is present in animals but not bacteria or yeast. PMID: 27257063
5. TOP3B promotes transcription, protects against DNA damage, and reduces the frequency of chromosomal translocations. PMID: 24507716
6. Topoisomerase IIIbeta expression can be a useful marker in assessing the prognosis of patients with breast cancer and is an independent predictor of survival. PMID: 20950730
7. the positive regulatory region including the 5'GGAACC3' core element is essential for efficient expression of the DNA topoisomerase III beta gene PMID: 15358519
8. Two isoforms of human DNA topoisomerase IIIbeta were expressed in HeLa cells. Isoform 1 was localized to the nucleus and associated with chromosomes during metaphase and anaphase. Isoform 2 was found in the cytoplasm. PMID: 11549288

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HGNC: 11993

OMIM: 603582

KEGG: hsa:8940

STRING: 9606.ENSP00000349705

UniGene: Hs.436401