TP53BP2 Antibody

1. Study have provided evidence that ASPP2 has an inhibitory influence on triplenegative breast cancer (TNBC) growth and metastasis, and that this may rely on using the PI3K/AKT pathway in a p53independent manner. PMID: 29568874
2. the abnormal expression of ASPP2 may play an important role for development and metastasis in esophageal squamous cell carcinoma. PMID: 29747775
3. These findings identify TP53BP2 as a strong candidate causative gene for central nervous system (CNS) defects in 1q41q42 microdeletion syndrome. PMID: 27447114
4. Results showed that protein expression levels of ASPP2 and P53 were significantly higher in esophageal squamous cell carcinoma tissues than in paired noncancerous tissues. PMID: 28103919
5. Expression levels of TP53BP2, FBXO28, and FAM53A genes were associated with patient survival specifically in ER-positive, TP53-mutated tumors. PMID: 28179588
6. These data together implicated a critical impact of MiR-205/ASPP2 on promoting epithelial-mesenchymal transition. PMID: 27929537
7. ASPP2 is a key regulator of BECN1-dependent autophagy. PMID: 27929538
8. Our results suggest that Gal-1 and ASPP2 functionally compete in nanocluster for active Ras on the plasma membrane. ASPP2 dominates the biological outcome, thus switching from a Gal-1 supported growth-promoting setting to a senescence inducing and stemness suppressive program in cancer cells. Our results support Ras nanocluster as major integrators of tumour fate decision events. PMID: 27437940
9. Downregulated expression of ASPP2 is associated with hepatocellular carcinoma. PMID: 27473084
10. miR-548d-3p/TP53BP2 pathway is critically involved in the proliferation and apoptosis of breast cancer cells and may be new therapeutic target of breast cancer cells. PMID: 26663100
11. ASPP1/2-PP1 complexes are required for chromosome segregation and kinetochore-microtubule attachments. PMID: 26595804
12. ASSP2 expression is lower in cancerous tissues and decreased ASPP2 lead to higher cancer cells proliferation and autophagic flux, which contribute to the gemcitabine resistance. PMID: 26438046
13. this study revealed a novel function of ASPP2 in modulating autophagy and apoptosis. PMID: 25534115
14. ASPP2 may participate in the lipid metabolism of non-alcoholic steatohepatitis and attenuate liver failure. PMID: 25256142
15. These results identify previously uncharacterized regions distributed throughout the protein sequence of ASPP2 as determinants of CagA binding, providing mechanistic insight into apoptosis reprogramming by CagA. PMID: 25963096
16. ASPP2 directly induces the dephosphorylation and activation of junctional YAP PMID: 25360797
17. CHOP is critical for mediating ASPP2-induced autophagic apoptosis by decreasing Bcl-2 expression and maintaining nuclear ASPP2-Bcl-2 complexes. PMID: 25032846
18. ASPP1/2 interacted with centrosome linker protein C-Nap1. Co-depletion of ASPP1 and ASPP2 inhibited re-association of C-Nap1 with centrosome at the end of mitosis. PMID: 25660448
19. these observations reveal that Itch and Yap1 have antagonistic roles in the regulation of ASPP2 protein stability through competing post-translational regulatory mechanism of ASPP2. PMID: 25436413
20. phosphorylation of ASPP2 by RAS/MAPK pathway provides a novel link between RAS and p53 in regulating apoptosis PMID: 24312625
21. Attenuated expression of apoptosis stimulating protein of p53-2 (ASPP2) in human acute leukemia is associated with therapy failure. PMID: 24312201
22. higher rate Helicobacter pylori infection, an increased expression of inhibitor of apoptosis stimulating protein of p53 (iASPP), and decreased expression of apoptosis-stimulating of p53 protein 2(ASPP2) was present in gastric cancer PMID: 23528480
23. our studies demonstrate the role of Siah2 in regulation of tight junction integrity and cell polarity under hypoxia, through its regulation of ASPP2 stability. PMID: 23644657
24. Disruption of CagA and ASPP2 binding alters the function of ASPP2 and leads to the decreased survival of H. pylori-infected cells PMID: 24474782
25. FIH-1 depletion did lead to impaired binding of Par-3 to ASPP2. PMID: 23606740
26. We also unveiled a possible mechanistic link between ASPP2 and Csk/Src signaling pathway, implicating the multiple cellular functions of ASPP2. PMID: 23671128
27. ASPP1 and ASPP2 cooperate with RAS to enhance p53-induced apoptosis suggests that loss of ASPP1 or ASPP2 expression may be a frequent event in human cancers with mutant RAS. PMID: 23392125
28. When the Px(T)PxR motif is deleted or mutated via insertion of a phosphorylation site mimic (T311D), PP-1c fails to bind to all three ASPP proteins, ASPP1, ASPP2 and iASPP. PMID: 23088536
29. ASPP2 binds to Ras-GTP at the plasma membrane and stimulates Ras-induced signaling and pERK1/2 levels via promoting Ras-GTP loading, B-Raf/C-Raf dimerization, and C-Raf phosphorylation. PMID: 23248303
30. the mRNA expression of ASPP1 and ASPP2 was frequently dowregulated in tumor tissues, and this decreased significantly in samples expressing wild-type p53 PMID: 22552744
31. Methylation in the promoter region of ASPP2 gene was not detected in lung cancer or adjacent non-neoplastic lung tissue. PMID: 22169642
32. Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host PMID: 21562218
33. PP1A and ASPP2 play a critical role in promoting TAZ function by antagonizing the LATS kinase through TAZ dephosphorylation. PMID: 21189257
34. study was to determine localization pattern of ASPP-2 in a variety of normal and malignant human tissues; study indicates that ASPP-2 has a specific distribution pattern within tissues and cells in a way that appears to be related to differentiation PMID: 21183427
35. ASPP2(ANK-SH3) binds NFkappaB(p65) in a similar manner to its natural inhibitor IkappaB, suggesting a possible novel role for ASPP2 as an NFkappaB inhibitor PMID: 19507243
36. ASPP1 and ASPP2 genes are frequently down-regulated by DNA methylation in HBV-positive hepatocellular carcinoma, which may play important roles in the development of HCC PMID: 20034025
37. ASPP2 is a negative regulator of the neddylation pathway through specific interaction with APP-BP1 and suggest that dysfunction of the APP-BP1 interaction with APP may be one cause of Alzheimer's disease PMID: 12694406
38. TP53BP2 encodes two mRNA species, either with (53BP2) or without exon 3 (ASPP2), by alternative splicing in various cell lines and tissues PMID: 14766226
39. downstream of E2F, suggesting that it functions as a common link between the p53/p73 and Rb/E2F apoptotic pathways PMID: 15592436
40. target of E2F transcription factor PMID: 15731768
41. ASPP2 CpG island aberrant methylation could be one molecular and genetic alteration in wild-type p53 tumours. PMID: 15757645
42. results suggest that the tumor protein p53 binding protein(TP53BP2) locus is associated with susceptibility to gastric cancer in the Korean population PMID: 15986435
43. ASPP2/(53BP2L) expression regulation by proteasomal degradation modulates p53 apoptotic function PMID: 16091363
44. In this study we explored the effect of NF-kappaB activation elicited by a physiological NF-kappaB inducer, interleukin-1beta (IL-1beta), and anti-apoptotic Bcl-2 family proteins on the 53BP2S-mediated apoptosis PMID: 16098144
45. role of ASPP1, ASPP2, and iASPP as apoptotic specific regulators of p53 [review] PMID: 16139958
46. suggest a possible role for the N-termini of ASPP proteins in binding to other proteins in the apoptotic response network PMID: 17594908
47. 53BP2S interacts and modulates the insulin signals mediated by insulin receptor substrates. PMID: 17965023
48. identifies the interaction sites of Bcl-2 and its homologues with ASPP2 PMID: 18719108
49. bcl2 -938C/C genotype has worse prognosis and lower survival in patients with renal cell carcinoma. In addition, the bcl2 -938C/A single nucleotide polymorphism was shown to be an independent adverse prognostic factor for renal cell carcinoma PMID: 19539330

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HGNC: 12000

OMIM: 602143

KEGG: hsa:7159

STRING: 9606.ENSP00000341957

UniGene: Hs.523968