TP53I3 Antibody

1. Results revealed that PIG3 expression levels positively correlated with poor prognosis of non-small cell lung cancer (NSCLC) patients and indicate that PIG3 promotes NSCLC progression. PMID: 28259183
2. Data suggest that PIG3 was involved in HIF-1alpha regulation, and indicate a signaling pathway of PIG3/HIF-1alpha in the regulation of cell migration in renal cell carcinoma. PMID: 27029070
3. our data suggest that high expression of p53-inducible gene 3 is significant for glioblastoma inhibition and p53-inducible gene 3 independently indicates good prognosis in patients, which might be a novel prognostic biomarker or potential therapeutic target in glioblastoma. PMID: 28351326
4. Data indicate that knockdown of p53-induced gene 3 (PIG-3) expression by small interfering RNA (siRNA) treatment can inhibit the generation of reactive oxygen species (ROS). PMID: 26472723
5. The results suggested that PIG3 plays an oncogenic role in PTC via the regulation of the PI3K/AKT/PTEN pathway and support the exploration of PIG3 as a novel biomarker for patients with papillary thyroid carcinoma PMID: 26133772
6. PIG3, which functions in DNA damage repair, uses an unexpected catalytic mechanism to suppress Rho-ROCK activity and impair tumor invasion in vivo. This regulation was suppressed by antioxidants. PMID: 26464464
7. prohibitin and prohibiton (PHB2) contribute to PIG3-mediated apoptosis by binding to the PIG3 promoter (TGYCC)15 motif PMID: 24388982
8. study provides evidence that the variant genotypes of (TGYCC)n repeats in the PIG3 promoter are functional and associated with risk of squamous cell carcinoma of the head and neck in a non-Hispanic white population PMID: 23241165
9. a novel signaling pathway of GPx3-PIG3 in the regulation of cell death in prostate cancer. PMID: 22461624
10. certain p53 mutatants activate PIG3, whereas the result of our study show increased full-length transcript expression in tumor counterparts PMID: 20603616
11. Results suggest that PIG3 is a critical component of the DNA damage response pathway and has a direct role in the transmission of the DNA damage signal from damaged DNA to the intra-S and G2/M checkpoint machinery. PMID: 20023697
12. p53 activity and PIG3 gene function are uncoupled by UV-dependent alternative splicing through rapid proteolytic degradation PMID: 15067011
13. suppression of p53-C277Y by RNAi reduced pig3 promoter activity, RNA, and protein expression PMID: 15192123
14. numerous factors contribute to the normal alternative splicing of PIG3 exon 4 and UV-inducible increases in this process require that the splicing of this exon be maintained in a sufficiently weakened state under normal conditi PMID: 18801469
15. PIG3 action is through oxidative stress produced by its enzymatic activity and provides essential knowledge for eventual control of apoptosis. PMID: 19349281

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HGNC: 19373

OMIM: 605171

KEGG: hsa:9540

STRING: 9606.ENSP00000238721

UniGene: Hs.50649