TRIM16 Antibody

1. High TRIM16 expression is associated with drug resistance in Non-Small Cell Lung Cancer. PMID: 29295721
2. TRIM16 inhibits the migration and invasion via suppressing the Sonic hedgehog signaling pathway in ovarian cancer cells. PMID: 27737724
3. The cooperation between TRIM16 and Galectin-3 in targeting and activation of selective autophagy protects cells from lysosomal damage and Mycobacterium tuberculosis invasion. PMID: 27693506
4. TRIM16 expression is decreased in prostate cancer tissues and overexpression of TRIM16 inhibits cell migration, invasion and the EMT process in vitro in prostate cancer through the transcription factor Snail. PMID: 27748839
5. Results found that the expression of TRIM16 was significantly downregulated in hepatocellular carcinoma cell (HCC) lesions and define TRIM16 as an inhibitor of epithelial-mesenchymal transition and metastasis in HCC. PMID: 26892350
6. TRIM16 directly regulated the degradation of Gli1 protein via the ubiquitinproteasome pathway. TRIM16 expression was low in breast cancer. It negatively correlated with metastasis and suppressed stem-cell properties in breast cancer cells. PMID: 26718507
7. Data suggest that TRIM16 and TDP43 are both good prognosis indicators; data shows that TRIM16 inhibits cancer cell viability by a novel mechanism involving interaction and stabilisation of TDP43 with consequent effects on E2F1 and pRb proteins. PMID: 26902425
8. Expression of SDMGC and TRIM16 was upregulated in the distant metastasis tissues PMID: 25866896
9. Chromatin immunoprecipitation assays revealed TRIM16 directly bound the IFNbeta1 gene promoter. Low level TRIM16 expression in 91 melanoma patient samples, strongly correlated with lymph node metastasis, and, predicted poor patient prognosis. PMID: 25333256
10. results suggest that TRIM16 is a potential pharmacologic target for the treatment of NSCLC and promotion TRIM16 expression might represent a novel strategy to NSCLC metastasis PMID: 25843803
11. TRIM16 can promote apoptosis by directly modulating caspase-2 activity in cancer cells. PMID: 23404198
12. data suggest that TRIM16 acts as a novel regulator of both neuroblastoma G 1/S progression and cell differentiation PMID: 23422002
13. via its unique structure, TRIM16 possesses both heterodimerization function with other TRIM proteins and also has E3 ubiquitin ligase activity. PMID: 22629402
14. TRIM16 acts as a tumour suppressor, affecting neuritic differentiation, cell migration and replication through interactions with cytoplasmic vimentin and nuclear E2F1 in neuroblastoma cells. PMID: 20729920
15. role in regulating keratinocyte differentiation PMID: 11919186
16. These results provide evidence for a role of EBBP in innate immunity by enhancing the alternative secretion pathway of IL-1beta. PMID: 16575408
17. EBBP increased betaRARE-transactivating function through its coiled-coil domain PMID: 16636064
18. The estrogen-responsive B box protein (EBBP) restores retinoid sensitivity in retinoid-resistant cancer cells via effects on histone acetylation. PMID: 19147277

Show More

Hide All

HGNC: 17241

OMIM: 609505

KEGG: hsa:10626

STRING: 9606.ENSP00000338989

UniGene: Hs.123534