TRIM71 Antibody, FITC conjugated

Datasheet

Code	CSB-PA652403LC01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TRIM71 Polyclonal antibody

Uniprot No.

Q2Q1W2

Target Names

TRIM71

Alternative Names

2610206G21Rik antibody; Abnormal cell LINeage LIN 41 antibody; AL022943 antibody; E3 ubiquitin-protein ligase TRIM71 antibody; Gm1127 antibody; Homolog of C. elegans Lin 41 antibody; LIN 41 antibody; LIN41 antibody; LIN41_HUMAN antibody; mlin 41 antibody; Protein lin 41 homolog antibody; Protein lin-41 homolog antibody; RGD1566388 antibody; Ripply2 antibody; TRIM 71 antibody; TRIM71 antibody; Tripartite motif containing 71 antibody; Tripartite motif-containing protein 71 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human E3 ubiquitin-protein ligase TRIM71 protein (125-209AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1. Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression.

Gene References into Functions

TRIM71 acts through post-transcriptional repression of Lin28B and subsequent modulation of let-7-HMGA2 signaling during tumorigenesis to potentially function as a tumor suppressor. PMID: 27821801
Studies indicate most-studied TRIpartite Motif (TRIM)-NHL proteins TRIM2, TRIM3, TRIM32 and TRIM71, and their mutations have been linked to diseases. PMID: 26514622
Consistent with the let-7 microRNA stimulatory role of TRIM71 via Lin28B polyubiquitination. PMID: 24602972
poiopi poiopi i90iy9oyu8 PMID: 23892092
The stem cell E3-ligase Lin-41 promotes liver cancer progression through inhibition of microRNA-mediated gene silencing. PMID: 23097274
Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation PMID: 22735451
Repression of human TRIM71 and the zebrafish lin-41 ortholog was abolished when predicted let-7 target sites were mutated. Regulation of TRIM71 expression by let-7 seems to have been evolutionarily conserved. PMID: 17890240

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Subcellular Location

Cytoplasm, P-body.

Protein Families

TRIM/RBCC family

Tissue Specificity

Specifically expressed in testis.

Database Links

HGNC: 32669

KEGG: hsa:131405

STRING: 9606.ENSP00000373272

UniGene: Hs.113170

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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