TRIP13 Antibody

1. heightened TRIP13 expression appears to promote lung adenocarcinoma tumor progression. PMID: 29567476
2. TRIP13-p31(comet) intercepts and disassembles free mitotic checkpoint complex not bound to anaphase-promoting complex/cyclosome through mediating the local unfolding of the Mad2 C-terminal region. PMID: 29208896
3. Microarray analyses indicated that the biological function of TRIP13 in CLL is majorly cell apoptosis and cell proliferation associated. TRIP13 siRNA expressing cells exhibited a slower cell proliferation rate and underwent apoptosis compared with control cells. PMID: 28424416
4. TRIP13 ubiquitinates and degrades the checkpoint surveillance protein MAD2 via activating Akt signaling pathway, leading to weakened checkpoint surveillance and consequent tumorigenic aneuploidy and drug resistance in MM. PMID: 28157697
5. These results identify an unexpected dependency on TRIP13 in cells overexpressing Mad2. PMID: 28564602
6. 6 individuals with biallelic loss-of-function mutations in TRIP13 developed Wilms tumors. TRIP13-mutant patient cells have no detectable TRIP13 and have substantial impairment of the spindle assembly checkpoint (SAC), leading to a high rate of chromosome missegregation. Individuals with biallelic TRIP13 mutations have a high risk of embryonal tumors. These experiments show that their cells display severe SAC impairment. PMID: 28553959
7. Thes authors show that p31(comet) binding to the TRIP13 N-terminal domain positions the disordered MAD2 N-terminus for engagement by the TRIP13 "pore loops", which then unfold MAD2 in the presence of ATP. PMID: 28659378
8. These results establish a paradigm of the roles of p31(comet) and TRIP13 in both checkpoint activation and inactivation. PMID: 26832417
9. the oligomeric form of TRIP13 binds both p31(comet) and MCC PMID: 26324890
10. TRIP13 promotes error-prone non-homologous end joining and induces chemoresistance in head and neck cancer. PMID: 25078033
11. suggest that premature mitotic checkpoint silencing triggered by TRIP13 overexpression may promote cancer development PMID: 25012665
12. propose that TRIP13 plays centrally important roles in the sequence of events leading to MCC disassembly and checkpoint inactivation PMID: 25092294

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HGNC: 12307

OMIM: 604507

KEGG: hsa:9319

STRING: 9606.ENSP00000166345

UniGene: Hs.436187