TRMT5 Antibody

Code CSB-PA024541GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
TRMT5
Alternative Names
TRMT5 antibody; KIAA1393 antibody; TRM5 antibody; tRNA antibody; guanine(37)-N1)-methyltransferase antibody; EC 2.1.1.228 antibody; M1G-methyltransferase antibody; tRNA [GM37] methyltransferase antibody; tRNA methyltransferase 5 homolog antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human TRMT5
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in mitochondrial tRNA methylation. Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
Gene References into Functions
  1. TRMT5 mutations cause a defect in post-transcriptional modification of mitochondrial tRNA associated with multiple respiratory-chain deficiencies. PMID: 26189817
  2. Conservation of structure and mechanism by Trm5 enzymes PMID: 23887145
  3. comparison of human TRM5 and E Coli TrmD activities, requirements for optimal activity, and tRNA methylation sites PMID: 15248782
Involvement in disease
Combined oxidative phosphorylation deficiency 26 (COXPD26)
Subcellular Location
Mitochondrion matrix. Nucleus. Cytoplasm.
Protein Families
Class I-like SAM-binding methyltransferase superfamily, TRM5/TYW2 family
Database Links

HGNC: 23141

OMIM: 611023

KEGG: hsa:57570

STRING: 9606.ENSP00000261249

UniGene: Hs.380159

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