TSSK4 Antibody

Code CSB-PA877181
Size US$297
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  • Western blot analysis of extracts from HT-29 cells, using TSSK4 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TSSK4 Polyclonal antibody
Uniprot No.
Target Names
TSSK4
Alternative Names
C14orf20 antibody; Serine/threonine-protein kinase 22E antibody; STK22E antibody; Testis-specific kinase 4 antibody; Testis-specific serine/threonine-protein kinase 4 antibody; TSK-4 antibody; TSSK-4 antibody; Tssk4 antibody; TSSK4_HUMAN antibody; TSSK5 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from internal of Human TSSK4.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Serine/threonine kinase which is involved in male germ cell development and in mature sperm function. May be involved in the Cre/Creb signaling pathway. Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells. Phosphorylates CREM on 'Ser-116' in vitro. Phosphorylates ODF2 on 'Ser-95'.
Gene References into Functions
  1. TSSK4 was able to induce cell apoptosis in vitro depending on its kinase activity, which leads to abnormal testes weight and apoptosis, shedding light on its function in the process of spermatogenesis and/or spermiogenesis PMID: 25877358
  2. Observational study of gene-disease association. (HuGE Navigator) PMID: 20378615
  3. association of some single nucleotide polymorphisms in TSSK4 with male infertility. PMID: 18390560
  4. Observational study of gene-disease association. (HuGE Navigator) PMID: 18390560
Subcellular Location
Cytoplasmic vesicle, secretory vesicle, acrosome. Cell projection, cilium, flagellum.
Protein Families
Protein kinase superfamily, CAMK Ser/Thr protein kinase family
Tissue Specificity
Expressed only in the testis.
Database Links

HGNC: 19825

OMIM: 610711

KEGG: hsa:283629

STRING: 9606.ENSP00000339179

UniGene: Hs.314432

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA
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