TTLL3 Antibody, HRP conjugated

Code CSB-PA23329B0Rb
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TTLL3 Polyclonal antibody
Uniprot No.
Target Names
TTLL3
Alternative Names
HOTTL antibody; PRO0207 antibody; Ttll3 antibody; TTLL3_HUMAN antibody; Tubulin monoglycylase TTLL3 antibody; Tubulin tyrosine ligase like protein 3 antibody; Tubulin--tyrosine ligase-like protein 3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Tubulin monoglycylase TTLL3 protein (470-641AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Monoglycylase which modifies alpha- and beta-tubulin, adding a single glycine on the gamma-carboxyl groups of specific glutamate residues to generate monoglycine side chains within the C-terminal tail of tubulin. Not involved in elongation step of the polyglycylation reaction. Preferentially glycylates a beta-tail peptide over the alpha-tail, although shifts its preference toward alpha-tail as beta-tail glutamylation increases. Competes with polyglutamylases for modification site on beta-tubulin substrate, thereby creating an anticorrelation between glycylation and glutamylation reactions. Together with TTLL8, mediates microtubule glycylation of primary and motile cilia, which is essential for their stability and maintenance. Involved in microtubule glycylation of primary cilia in colon which controls cell proliferation of epithelial cells and plays an essential role in colon cancer development. Together with TTLL8, glycylates sperm flagella which regulates axonemal dynein motor activity, thereby controlling flagellar beat, directional sperm swimming and male fertility.
Gene References into Functions
  1. Characterization of another human tubulin tyrosine ligase-like gene family member PMID: 11054573
Subcellular Location
Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.
Tissue Specificity
Expressed in brain, heart, kidney, testis, liver, lung, muscle, spleen, trachea and colon.
Database Links

HGNC: 24483

KEGG: hsa:26140

STRING: 9606.ENSP00000392549

UniGene: Hs.726435

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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