TUB Antibody

1. Tubby and Tulp1 mediated phagocytosis through MerTK-dependent signaling with non-muscle myosin II redistribution leading to colocalization of phagocytosed vesicles with rearranged NMMIIA. PMID: 24664737
2. Tubby and Tulp1 are bridging molecules with their N-terminal region as MERTK-binding domain and C-terminal region as phagocytosis prey-binding domain. PMID: 20978472
3. Tubby and Tulp1 function as phagocytosis sigmals (eat-me) for retinal pigment epithelium cells and other phagocytes. PMID: 19837063
4. TUB could be an important factor in controlling the central regulation of body weight in humans. PMID: 16443771
5. found the presence of tubby protein both in normal weight and in obese subjects; however in the latter an isoelectric point shift toward the acidic end was observed PMID: 17498679
6. TUB is a candidate gene for late-onset obesity in humans PMID: 17955208
7. Genetic variation of the TUB gene was associated with both body composition and macronutrient intake, suggesting that TUB might influence eating behavior PMID: 18183286
8. Mouse Tubby protein may function as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, providing a direct link between G-protein signaling and the regulation of gene expression. PMID: 11375483
9. Crystal structure of the core domain of the mouse Tubby protein. PMID: 10591637

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HGNC: 12406

OMIM: 601197

KEGG: hsa:7275

STRING: 9606.ENSP00000305426

UniGene: Hs.568986