TXNRD1 Antibody

Datasheet
Code CSB-PA613705LA01HU
See More Details Free Antibody trial simple
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Uniprot No. Q16881
Image
  • Western blot
    All lanes: TXNRD1 antibody at 5µg/ml
    Lane 1: Jurkat whole cell lysate
    Lane 2: A549 whole cell lysate
    Lane 3: MCF-7 whole cell lysate
    Lane 4: Hela whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 71, 60, 66, 61, 55, 68, 51 kDa
    Observed band size: 60 kDa

  • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA613705LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA613705LA01HU at dilution of 1:100

Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Recombinant Human Thioredoxin reductase 1, cytoplasmic protein (1-497AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200
Relevance Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Thioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (Gene associated with retinoic and interferon-induced mortality 12 protein) (GRIM-12) (Gene associated with retinoic and IFN-induced mortality 12 protein) (KM-102-derived reductase-like factor) (Thioredoxin reductase TR1), TXNRD1, GRIM12 KDRF
Immunogen Species Human
Research Area Signal Transduction
Target Names TXNRD1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
Subcellular Location Cytoplasm, SUBCELLULAR LOCATION: Isoform 4: Cytoplasm, Nucleus, SUBCELLULAR LOCATION: Isoform 5: Cytoplasm
Protein Families Class-I pyridine nucleotide-disulfide oxidoreductase family
Tissue Specificity Isoform 1 is expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines. Isoform 4 is widely expressed with highest levels in kidney, testis, uterus,
Database Links

HGNC: 12437

OMIM: 601112

KEGG: hsa:7296

STRING: 9606.ENSP00000434516

UniGene: Hs.654922

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