UACA Antibody

Code CSB-PA025409ESR1HU
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
Image
  • Western blot
    All lanes: UACA antibody at 5.51µg/ml
    Lane 1: Hela whole cell lysate
    Lane 2: A549 whole cell lysate
    Lane 3: Jurkat whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 163, 162 kDa
    Observed band size: 163, 140 kDa

  • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA025409ESR1HU at dilution of 1:100

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Product Details

Description

CUSABIO uses the recombinant human uveal autoantigen with coiled-coil domains and ankyrin repeats (UACA) protein (1-90AA) to immunize rabbits to obtain anti-serum, which is antigen affinity purified to get the UACA polyclonal antibody. This UACA antibody exists as an unconjugated IgG. It only shows reactivity with human UACA protein. And it has been validated for use in ELISA, WB, and IHC applications. The target protein UACA regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis.

Full Product Name Rabbit anti-Homo sapiens (Human) UACA Polyclonal antibody
Uniprot No. Q9BZF9
Target Names UACA
Alternative Names FLJ10128 antibody; KIAA1561 antibody; MGC141967 antibody; MGC141969 antibody; Nuclear membrane binding protein antibody; NUCLING antibody; UACA antibody; UACA_HUMAN antibody; Uveal autoantigen with coiled coil domains and ankyrin repeats antibody; Uveal autoantigen with coiled-coil domains and ankyrin repeats antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (1-90AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form Liquid
Tested Applications ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Applications : Enhanced Green Fluorescent Portein (EGFP) assay

Sample type: Human Serum

Review: EGFP assays showed cropped images of autoantibodies against Sp17 on protein chips. Green fluorescence represents the results of serum autoantibody signals; red fluorescence produced by the anti-GST antibody represents protein loading.

By Anonymous

Target Background

Function
(From Uniprot)
Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity).
Gene References into Functions
  1. Lycopene inhibits RCAN1-mediated apoptosis by reducing ROS levels and by inhibiting NF-kappaB activation, Nucling induction, and the increase in apoptotic indices in neuronal cells. PMID: 27928873
  2. The down-regulation of APIP and UACA expression suggests that the threshold to activate the apoptosome apparatus may be decreased in non-small cell lung cancer cells. PMID: 22407486
  3. UACA is a novel candidate for eye muscle autoantigens in thyroid-associated ophthalmopathy PMID: 15358194
Subcellular Location Nucleus, Cytoplasm, Cytoplasm, cytoskeleton
Tissue Specificity Highly expressed in skeletal muscle, heart, kidney and pancreas. Expressed in choroid, retina and epidermal melanocytes. Expressed in eye muscles and thyroid follicular cells.
Database Links

HGNC: 15947

OMIM: 612516

KEGG: hsa:55075

STRING: 9606.ENSP00000314556

UniGene: Hs.108049

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