Your Good Partner in Biology Research
Your Good Partner in Biology Research
| Code | CSB-PA025409ESR1HU |
| Size |
US$299Purchase it in Cusabio online store (only available for customers from the US) |
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| Description |
CUSABIO uses the recombinant human uveal autoantigen with coiled-coil domains and ankyrin repeats (UACA) protein (1-90AA) to immunize rabbits to obtain anti-serum, which is antigen affinity purified to get the UACA polyclonal antibody. This UACA antibody exists as an unconjugated IgG. It only shows reactivity with human UACA protein. And it has been validated for use in ELISA, WB, and IHC applications. The target protein UACA regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. |
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| Full Product Name | Rabbit anti-Homo sapiens (Human) UACA Polyclonal antibody | ||||||
| Uniprot No. | Q9BZF9 | ||||||
| Target Names | UACA | ||||||
| Alternative Names | FLJ10128 antibody; KIAA1561 antibody; MGC141967 antibody; MGC141969 antibody; Nuclear membrane binding protein antibody; NUCLING antibody; UACA antibody; UACA_HUMAN antibody; Uveal autoantigen with coiled coil domains and ankyrin repeats antibody; Uveal autoantigen with coiled-coil domains and ankyrin repeats antibody | ||||||
| Raised in | Rabbit | ||||||
| Species Reactivity | Human | ||||||
| Immunogen | Recombinant Human Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (1-90AA) | ||||||
| Immunogen Species | Homo sapiens (Human) | ||||||
| Conjugate | Non-conjugated | ||||||
| Clonality | Polyclonal | ||||||
| Isotype | IgG | ||||||
| Purification Method | Antigen Affinity Purified | ||||||
| Concentration | It differs from different batches. Please contact us to confirm it. | ||||||
| Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. | ||||||
| Form | Liquid | ||||||
| Tested Applications | ELISA, WB, IHC | ||||||
| Recommended Dilution |
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| Protocols | ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol |
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| Troubleshooting and FAQs | Antibody FAQs | ||||||
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | ||||||
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
Applications : Enhanced Green Fluorescent Portein (EGFP) assay
Sample type: Human Serum
Review: EGFP assays showed cropped images of autoantibodies against Sp17 on protein chips. Green fluorescence represents the results of serum autoantibody signals; red fluorescence produced by the anti-GST antibody represents protein loading.
By Anonymous
| Function |
Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1.; Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation.
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| Gene References into Functions |
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| Subcellular Location | Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Expressed diffusely in cytoplasm. |
| Tissue Specificity | Highly expressed in skeletal muscle, heart, kidney and pancreas. Expressed in choroid, retina and epidermal melanocytes. Expressed in eye muscles and thyroid follicular cells. |
| Database Links |
HGNC: 15947 OMIM: 612516 KEGG: hsa:55075 STRING: 9606.ENSP00000314556 UniGene: Hs.108049 |
