UACA Antibody

Code CSB-PA786520
Size US$299
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA786520(UACA Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: ×200)
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Product Details

Uniprot No. Q9BZF9
Target Names UACA
Alternative Names FLJ10128 antibody; KIAA1561 antibody; MGC141967 antibody; MGC141969 antibody; Nuclear membrane binding protein antibody; NUCLING antibody; UACA antibody; UACA_HUMAN antibody; Uveal autoantigen with coiled coil domains and ankyrin repeats antibody; Uveal autoantigen with coiled-coil domains and ankyrin repeats antibody
Raised in Rabbit
Species Reactivity Human,Mouse
Immunogen Fusion protein of Human UACA
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method Antigen affinity purification
Concentration It differs from different batches. Please contact us to confirm it.
Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form Liquid
Tested Applications ELISA,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:10000
IHC 1:30-1:150
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1.; Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation.
Gene References into Functions
  1. Lycopene inhibits RCAN1-mediated apoptosis by reducing ROS levels and by inhibiting NF-kappaB activation, Nucling induction, and the increase in apoptotic indices in neuronal cells. PMID: 27928873
  2. The down-regulation of APIP and UACA expression suggests that the threshold to activate the apoptosome apparatus may be decreased in non-small cell lung cancer cells. PMID: 22407486
  3. UACA is a novel candidate for eye muscle autoantigens in thyroid-associated ophthalmopathy PMID: 15358194
Subcellular Location Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Expressed diffusely in cytoplasm.
Tissue Specificity Highly expressed in skeletal muscle, heart, kidney and pancreas. Expressed in choroid, retina and epidermal melanocytes. Expressed in eye muscles and thyroid follicular cells.
Database Links

HGNC: 15947

OMIM: 612516

KEGG: hsa:55075

STRING: 9606.ENSP00000314556

UniGene: Hs.108049

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