UBAP2L Antibody, FITC conjugated

1. UBAP2L plays an oncogenic role in HCC, and knockdown of its expression significantly inhibits HCC growth and metastasis, which may be related to the regulation of PI3K/AKT and P53 signaling pathways by UBAP2L. PMID: 30291221
2. High UBAP2L expression is associated with breast cancer. PMID: 29196913
3. UBAP2L was overexpressed in HCC, and patients with high UBAP2L expression had unfavorable prognosis. PMID: 28981479
4. UBAP2L is amplified in 15% of human primary lung adenocarcinoma specimens. Such patients express higher levels of UBAP2L and show a reduction in survival when compared with those who do not have this gene amplification. PMID: 28754713
5. UBAP2L plays a critical role in maintenance of the metastatic ability of Hepatocellular Carcinoma Cells cells via SNAIL1 Regulation and is predictive of a poor clinical outcome. PMID: 28334716
6. These results suggest that UBAP2L has a key role in glioma cell growth, and may act as an oncogene to promote malignant glioma development. PMID: 26310274
7. arginine residues in the RGG/RG motif of UBAP2L were directly methylated by PRMT1. RGG/RG motif of UBAP2L is essential for the proper alignment of chromosomes. PMID: 26381755
8. Knockdown of UBAP2L in prostate carcinoma inhibited cell proliferation, migration, and colony formation ability, and blocked cell cycle progression. PMID: 25069639
9. Two different BMI1-containing PcG complexes regulate hematopoietic stem cell activity, which are distinguishable by the presence of UBAP2L. PMID: 25185265

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HGNC: 29877

OMIM: 616472

KEGG: hsa:9898

STRING: 9606.ENSP00000355343

UniGene: Hs.490551