UBAP2L Antibody, HRP conjugated

Code CSB-PA622754LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) UBAP2L Polyclonal antibody
Uniprot No.
Target Names
UBAP2L
Alternative Names
FLJ42300 antibody; KIAA0144 antibody; NICE 4 antibody; NICE4 antibody; Protein NICE-4 antibody; Protein NICE4 antibody; Ubap2l antibody; Ubiquitin associated protein 2 like antibody; Ubiquitin-associated protein 2-like antibody; UBP2L_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Ubiquitin-associated protein 2-like protein (104-252AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs). Required for efficient formation of stress granules.
Gene References into Functions
  1. UBAP2L plays an oncogenic role in HCC, and knockdown of its expression significantly inhibits HCC growth and metastasis, which may be related to the regulation of PI3K/AKT and P53 signaling pathways by UBAP2L. PMID: 30291221
  2. High UBAP2L expression is associated with breast cancer. PMID: 29196913
  3. UBAP2L was overexpressed in HCC, and patients with high UBAP2L expression had unfavorable prognosis. PMID: 28981479
  4. UBAP2L is amplified in 15% of human primary lung adenocarcinoma specimens. Such patients express higher levels of UBAP2L and show a reduction in survival when compared with those who do not have this gene amplification. PMID: 28754713
  5. UBAP2L plays a critical role in maintenance of the metastatic ability of Hepatocellular Carcinoma Cells cells via SNAIL1 Regulation and is predictive of a poor clinical outcome. PMID: 28334716
  6. These results suggest that UBAP2L has a key role in glioma cell growth, and may act as an oncogene to promote malignant glioma development. PMID: 26310274
  7. arginine residues in the RGG/RG motif of UBAP2L were directly methylated by PRMT1. RGG/RG motif of UBAP2L is essential for the proper alignment of chromosomes. PMID: 26381755
  8. Knockdown of UBAP2L in prostate carcinoma inhibited cell proliferation, migration, and colony formation ability, and blocked cell cycle progression. PMID: 25069639
  9. Two different BMI1-containing PcG complexes regulate hematopoietic stem cell activity, which are distinguishable by the presence of UBAP2L. PMID: 25185265

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Subcellular Location
Cytoplasm, Stress granule.
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 29877

OMIM: 616472

KEGG: hsa:9898

STRING: 9606.ENSP00000355343

UniGene: Hs.490551

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