UBE2L6 Antibody

Datasheet

Code	CSB-PA025466LA01HU
Size	US$166
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Image	Immunofluorescent analysis of Hela cells using CSB-PA025466LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) UBE2L6 Polyclonal antibody

Uniprot No.

O14933

Target Names

UBE2L6

Alternative Names

MGC40331 antibody; Retinoic acid induced gene B protein antibody; Retinoic acid-induced gene B protein antibody; RIG B antibody; RIG-B antibody; UB2L6_HUMAN antibody; UBCH 8 antibody; UbcH8 antibody; UBE2L6 antibody; Ubiquitin carrier protein antibody; Ubiquitin carrier protein L6 antibody; Ubiquitin conjugating enzyme E2L 6 antibody; Ubiquitin protein ligase antibody; Ubiquitin protein ligase L6 antibody; Ubiquitin-protein ligase L6 antibody; Ubiquitin/ISG15 conjugating enzyme E2 L6 antibody; Ubiquitin/ISG15-conjugating enzyme E2 L6 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Ubiquitin/ISG15-conjugating enzyme E2 L6 protein (13-153AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The UBE2L6 Antibody (Product code: CSB-PA025466LA01HU) is Non-conjugated. For UBE2L6 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA025466LB01HU	UBE2L6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA025466LC01HU	UBE2L6 Antibody, FITC conjugated
Biotin	CSB-PA025466LD01HU	UBE2L6 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IF

Recommended Dilution

Application	Recommended Dilution
IF	1:50-1:200

Protocols

ELISA Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.

Gene References into Functions

Depletion of either ISG15 or UBE2L6/UBCH8 resulted in enhanced endogenous autophagic flux. PMID: 28186990
Data indicate that reduced expression of the ubiquitin-conjugating enzyme UbcH8 protein correlated with poor outcome in nasopharyngeal carcinoma (NPC) patients. PMID: 26506425
gain and loss-of-function approaches show that UBCH8 and the ubiquitin-ligase SIAH1 physically interact with and target FLT3-ITD for proteasomal degradation PMID: 20508617
Quantitative-PCR and Northern analysis confirmed down-regulation of UCRP and UBE2L6 with BRCA2 knockdown, respectively. PMID: 15670748

Protein Families

Ubiquitin-conjugating enzyme family

Tissue Specificity

Present in natural killer cells (at protein level).

Database Links

HGNC: 12490

OMIM: 603890

KEGG: hsa:9246

STRING: 9606.ENSP00000287156

UniGene: Hs.425777

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Ubiquitin mediated proteolysis

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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