UBE2L6 Antibody, Biotin conjugated

Code CSB-PA025466LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) UBE2L6 Polyclonal antibody
Uniprot No.
Target Names
UBE2L6
Alternative Names
MGC40331 antibody; Retinoic acid induced gene B protein antibody; Retinoic acid-induced gene B protein antibody; RIG B antibody; RIG-B antibody; UB2L6_HUMAN antibody; UBCH 8 antibody; UbcH8 antibody; UBE2L6 antibody; Ubiquitin carrier protein antibody; Ubiquitin carrier protein L6 antibody; Ubiquitin conjugating enzyme E2L 6 antibody; Ubiquitin protein ligase antibody; Ubiquitin protein ligase L6 antibody; Ubiquitin-protein ligase L6 antibody; Ubiquitin/ISG15 conjugating enzyme E2 L6 antibody; Ubiquitin/ISG15-conjugating enzyme E2 L6 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Ubiquitin/ISG15-conjugating enzyme E2 L6 protein (13-153AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.
Gene References into Functions
  1. Depletion of either ISG15 or UBE2L6/UBCH8 resulted in enhanced endogenous autophagic flux. PMID: 28186990
  2. Data indicate that reduced expression of the ubiquitin-conjugating enzyme UbcH8 protein correlated with poor outcome in nasopharyngeal carcinoma (NPC) patients. PMID: 26506425
  3. gain and loss-of-function approaches show that UBCH8 and the ubiquitin-ligase SIAH1 physically interact with and target FLT3-ITD for proteasomal degradation PMID: 20508617
  4. Quantitative-PCR and Northern analysis confirmed down-regulation of UCRP and UBE2L6 with BRCA2 knockdown, respectively. PMID: 15670748
Protein Families
Ubiquitin-conjugating enzyme family
Tissue Specificity
Present in natural killer cells (at protein level).
Database Links

HGNC: 12490

OMIM: 603890

KEGG: hsa:9246

STRING: 9606.ENSP00000287156

UniGene: Hs.425777

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