UBQLN1 Antibody

1. Thus, UBQLN1 plays an important role in clearing mislocalized mitochondrial proteins upon cell stimulation, and its absence leads to suppression of protein synthesis and cell cycle arrest. PMID: 28933694
2. UBQLN1 variant was not associated with the risk of Alzheimer's disease. PMID: 28719358
3. The STI and UBA Domains of UBQLN1 Are Critical Determinants of Substrate Interaction and Proteostasis. PMID: 28075048
4. Following the loss of UBQLN1 in lung adenocarcinoma cells, there is an accelerated loss of IGF1R. PMID: 29054976
5. The evidence of genetic associations has been found for the multivariate response phenotype that involves trans effects modulating expression of genes following heat shock, including HSF1 and UBQLN1. PMID: 27553423
6. The expression level of UBQLN1 and prognosis in breast cancer is clarified for the first time and UBQLN1 seems to be a novel molecular marker to predict poor prognosis in breast cancer. PMID: 26406952
7. The results suggest that UBQ-8i polymorphism may contribute to Alzheimer's disease susceptibility, but does not synergize with APOEepsilon4 status to increase Alzheimer's disease risk. PMID: 25010605
8. These results suggest that the UBQ-8i polymorphism is associated with Alzheimer's disease risk. PMID: 25387430
9. found that ZEB1 is required for induction of mesenchymal-like properties following loss of UBQLN1 and ZEB1 is capable of repressing expression of UBQLN1 PMID: 24747970
10. High UBQLN1 expression is associated with low radiosensitivity in breast cancer. PMID: 25044403
11. Ubiquilin-1 immunoreactivity is concentrated on Hirano bodies and dystrophic neurites in Alzheimer's disease PMID: 23421764
12. Human ubiquilin-1 overexpression in transgenic mice increases the lifespan and delays accumulation of Huntingtin aggregates in the R6/2 mouse model of Huntington's disease. PMID: 24475300
13. The results demonstrate that in Alzheimer's disease hippocampus, ubiquilin-1 immunoreactivity increases in the neuronal nucleoplasm and is associated with region-specific neurofibrillary changes. PMID: 23869942
14. Targeting of Ubqln1 to autophagosomes requires the Ubqln4 UBL domain and the Ubqln1 UBA domain. PMID: 23459205
15. data suggest that ubiquilin-1 modulates gamma-secretase-mediated epsilon-site cleavage and thus may play a role in regulating gamma-secretase cleavage of various substrates. PMID: 23663107
16. Genetic variants in UBQLN1 are not commonly associated with amyotrophic lateral sclerosis PMID: 22766032
17. This study demonistrated that Allele C of polymorphism UBQ-8i of the UBQLN1 gene is not an independent risk factor for mild cognitive impairment or Alzheimer's disease PMID: 22272618
18. Ubiquilin-1 was over-expressed following antiproliferative agents treatment of ovarian cancer cells. PMID: 22134777
19. ubiquilin-1 chaperone activity is necessary to regulate the production of APP and its fragments and that diminished ubiquilin-1 levels may contribute to AD pathogenesis. PMID: 21852239
20. PLIC-1 is a novel inhibitor of the TLR3-Trif antiviral pathway by reducing the abundance of Trif PMID: 21695056
21. specific ubiquilin-1 transcript variants can cause PS1 accumulation and aggresome formation PMID: 21143716
22. Data show that ubiquilin is degraded during both macroautophagy and during chaperone-mediated autophagy (CMA). PMID: 20529957
23. The UBQ-8i polymorphism of the UBQLN1 gene is extremely rare in Taiwan Chinese and unlikely to play a significant role in the risk of AD in Taiwan Chinese. PMID: 20350585
24. PLIC1 may be a regulator of HCV RNA replication through interaction with NS5B. Nn Huh7 cells that express an HCV subgenomic replicon, the amounts of both NS5B and the replicon RNA were reduced by overexpression of PLIC1. PMID: 12634373
25. Ubiquilin proteins play an important role in regulating PS protein levels in cells. PMID: 15004330
26. Ubiquilin-1 plays an active role in the precise regulation of HASH-1 and of other tissue-specific bHLH proteins PMID: 15492808
27. Our findings suggest that genetic variants in UBQLN1 on chromosome 9q22 substantially increase the risk of Alzheimer's disease, possibly by influencing alternative splicing of this gene in the brain PMID: 15745979
28. ubiquilin-1 limits the availability of unassembled nicotinic acetylcholine receptor subunits in neurons by drawing them to the proteosome, thus regulating nicotine-induced up-regulation PMID: 16091357
29. Genetic variation in the UBQLN1 gene has a modest effect on risk, age of onset and disease duration of Alaheimer's disease. PMID: 16302009
30. Overexpression of ubiquilin reduces cell death in HeLa cells and primary neurons stably expressing green fluorescent protein-huntingtin fusion protein. PMID: 16461334
31. Results suggest that UBQLN1 variants do not increase risk for Alzheimer disease. PMID: 16526030
32. Data show that ubiquilin 1 interacts both with presenilin 1 (PS1) holoprotein and heterodimer and that the interaction between PS1 and ubiquilin 1 takes place near the cell surface. PMID: 16815845
33. UBQLN1 modulates amyloid precursor protein trafficking and Abeta secretion. PMID: 16945923
34. These results indicate a role for PLIC-1 in the protein aggregation-stress pathway, and we propose a novel function for the ubiquitin-like (UBL) domain--by means of UBL-UIM interactions--in transport to aggresomes. PMID: 17082820
35. Mutation of two lysine residues in the PS2-loop region suggested that ubiquitination is not required for interaction with ubiquilin-1 and may, in fact, even negatively regulate the interaction. PMID: 17614368
36. Our results suggest that it is unlikely that the SNP rs12344615 of the UBQLN1 gene is related to the onset of AD, PD or cognitive function. PMID: 17709205
37. Expression of the human Alzheimer's disease-associated variant of UBQLN1 leads to more severe degeneration than does comparable expression of the human wildtype UBQLN1 in Drosophila eye. PMID: 17947293
38. The three-dimensional structure of the UBA domain of ubiquilin-1 (UQ1-UBA) free in solution and in complex with ubiquitin, is described. PMID: 18241885
39. Risk estimation for AA versus GG genotypes showed that the AA genotype is a weak risk factor for Alzheimer's disease PMID: 18340109
40. Plic-1 may play a significant role in regulating the strength of synaptic inhibition by increasing the stability of GABA(A)Rs within the secretory pathway and thereby promoting their insertion into the neuronal plasma membrane. PMID: 18467327
41. overexpression UBQLN1 transcript variants TV1-3, but not TV4, exert a protective effect during the unfolded protein response by attenuating CHOP induction and potentially increasing cell viability. PMID: 18953672
42. siRNA-mediated UBQLN1 depletion made cells more susceptible to starvation-induced cell death. UBQLN1 regulates cell survival during starvation. PMID: 19148225

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HGNC: 12508

OMIM: 605046

KEGG: hsa:29979

STRING: 9606.ENSP00000365576

UniGene: Hs.9589